How Adherens Junctions Move Cells During Collective Migration

Overview

Journal Fac Rev

Specialty Biomedical Engineering

Date 2021 Jul 26

PMID 34308422

Citations 10

Authors

Shafali Gupta

Alpha S Yap

Affiliations

Soon will be listed here.

Abstract

In this review, we consider how the association between adherens junctions and the actomyosin cytoskeleton influences collective cell movement. We focus on recent findings which reveal different ways for adherens junctions to promote the locomotion of cells within tissues: through lamellipodia and junctional contraction. These contributions reflect how classic cadherins establish sites of cortical actin assembly and how adherens junctions couple to contractile actomyosin, respectively. The diverse interplay between cadherin adhesion and the cytoskeleton thus provides different ways for adherens junctions to support epithelial locomotion.

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