The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Jul 26

PMID 34307155

Citations 3

Authors

Juan Xu

Xiyi Chen

Yu Sun

Yaqian Shi

Fang Teng

Mingming Lv

Chen Liu

Xuemei Jia

Affiliations

Soon will be listed here.

Abstract

Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been discovered and have proven to be clinically significant in the development and progression of breast cancer. Importantly, several regulators of circRNA biogenesis have been discovered. Here, we systematically summarize recent progress regarding the network of regulation governing the biogenesis, degradation, and distribution of circRNAs, and we comprehensively analyze the functions, mechanisms, and clinical significance of circRNA in breast cancer.

Citing Articles

Circular RNAs: New layer of complexity evading breast cancer heterogeneity.

Dawoud A, Ihab Zakaria Z, Hisham Rashwan H, Braoudaki M, Youness R Noncoding RNA Res. 2022; 8(1):60-74.

PMID: 36380816 PMC: 9637558. DOI: 10.1016/j.ncrna.2022.09.011.

Circular RNAs as Potential Biomarkers in Breast Cancer.

De Palma F, Salvatore F, Pol J, Kroemer G, Maiuri M Biomedicines. 2022; 10(3).

PMID: 35327527 PMC: 8945016. DOI: 10.3390/biomedicines10030725.

Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway.

Shi Y, Liu C BMC Cancer. 2021; 21(1):1249.

PMID: 34800978 PMC: 8605514. DOI: 10.1186/s12885-021-08989-w.

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