Prevention by the Natural Artocarpin of Morphological and Biochemical Alterations on UVB-Induced HaCaT Cells

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2021 Jul 26

PMID 34306307

Citations 3

Authors

Kunlathida Luangpraditkun

Marion Tissot

Anupong Joompang

Pensri Charoensit

Francois Grandmottet

Jarupa Viyoch

Celine Viennet

Affiliations

Soon will be listed here.

Abstract

Natural substances have gained considerable attention for skin protection against UV light reactions. plant's heartwood extract is comprised of artocarpin as a major substance, already known for its interesting biological attributes as an antimicrobial, an anti-inflammatory, an antioxidant, and a melanogenesis inhibitor. The present work clarified the mechanism of natural artocarpin (NAR) with a purity of approximately 99% against the effects of UVB-induced HaCaT keratinocyte apoptosis. The indicated results showed that NAR suppresses free radical production (ROS and nitrite) and apoptosis-related molecule activation (caspase-3, p-p53, p-p38, and NF-B p65) and secretion (TNF-). Additionally, NAR prevented structural damages (nuclei condensation and fragmentation, apoptotic body formation, impaired cell adherence and round cell shape, disruption of F-actin filament, and clustering of cell death receptor CD95/Fas) and biophysical changes (plasma membrane rigidification). Thus, NAR acts directly from scavenging free radicals generated by UV and indirectly by suppressing morphological and biochemical UV-induced cell damages. Its biological effects are mainly attributed to antioxidant and antiapoptotic properties. Taken together, NAR could be considered as an effective natural product for photoprotective formulations.

Citing Articles

Photoprotective Effects of Two New Morin-Schiff Base Derivatives on UVB-Irradiated HaCaT Cells.

Garcia-Gil S, Rodriguez-Luna A, Avila-Roman J, Rodriguez-Garcia G, Del Rio R, Motilva V Antioxidants (Basel). 2024; 13(1).

PMID: 38275659 PMC: 10813227. DOI: 10.3390/antiox13010134.

Antioxidant, Anti-Inflammation and Antiaging Activities of Methanolic Extract on Urban Particulate Matter-Induced HaCaT Keratinocytes Damage.

Yang C, Pan C, Tseng C, Yen F Antioxidants (Basel). 2022; 11(11).

PMID: 36421490 PMC: 9687219. DOI: 10.3390/antiox11112304.

Topical Nanoparticles Improved the Water Solubility and Skin Permeation of Raw Extract, Improving Its Photoprotective Effect.

Yang C, Huang P, Tseng C, Yen F Pharmaceutics. 2021; 13(9).

PMID: 34575454 PMC: 8469634. DOI: 10.3390/pharmaceutics13091372.

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