Pulmonary Artery Thrombosis: A Previously Overlooked Disease

Overview

Journal Front Pharmacol

Date 2021 Jul 26

PMID 34305592

Citations 14

Authors

Yunshan Cao

Chao Geng

Yahong Li

Yan Zhang

Affiliations

Soon will be listed here.

Abstract

Pulmonary thromboembolism (PTE) is the third leading cause of death in cardiovascular diseases. PTE is believed to be caused by thrombi detached from deep veins of lower extremities. The thrombi travel with systemic circulation to the lung and block pulmonary arteries, leading to sudden disruption of hemodynamics and blood gas exchange. However, this concept has recently been challenged by accumulating evidence demonstrating that de novo thrombosis may be formed in pulmonary arteries without deep venous thrombosis. On the other hand, chronic thromboembolic pulmonary hypertension (CTEPH), a subtype of pulmonary hypertension, could have different pathogenesis than traditional PTE. Therefore, this article summarized and compared the risk factors, the common and specific pathogenic mechanisms underlying PTE, in situ pulmonary artery thrombosis, and CTEPH at molecular and cellular levels, and suggested the therapeutic strategies to these diseases, aiming to facilitate understanding of pathogenesis, differential diagnosis, and precision therapeutics of the three pulmonary artery thrombotic diseases.

Citing Articles

Rounded Atelectasis with In-Situ Thrombosis in Supplying Artery.

Rollheiser K, Hilario Brugues M, Harvey Barnes J, Healey T J Brown Hosp Med. 2025; 4(1):34-37.

PMID: 40027454 PMC: 11864370. DOI: 10.56305/001c.127264.

From Pulmonary Embolism to Chronic Thromboembolic Pulmonary Hypertension: A Pathophysiological Approach.

Shahidi P, Mentzel L, Blazek S, Sulimov D, Thiele H, Fengler K Rev Cardiovasc Med. 2024; 25(11):402.

PMID: 39618872 PMC: 11607516. DOI: 10.31083/j.rcm2511402.

Arterial Thrombosis in Acute Respiratory Infections: An Underestimated but Clinically Relevant Problem.

Babkina A, Pisarev M, Grechko A, Golubev A J Clin Med. 2024; 13(19).

PMID: 39408067 PMC: 11477565. DOI: 10.3390/jcm13196007.

Pulmonary artery thrombosis due to patent ductus arteriosus: a case report.

Wang Y, Rong C, Lu M, Zhang W Front Cardiovasc Med. 2024; 11:1433847.

PMID: 39323756 PMC: 11423297. DOI: 10.3389/fcvm.2024.1433847.

CT Imaging Findings of Pulmonary Artery Stenosis: A Pictorial Review.

Zhang M, Chen L, Bu C, Zhang H, Luo J, Wang J Diagnostics (Basel). 2024; 14(16).

PMID: 39202250 PMC: 11353319. DOI: 10.3390/diagnostics14161762.

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