Ocular Surface Failure in Urban Syndrome

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Jul 24

PMID 34300214

Citations 6

Authors

Marco Antonini

Daniele Gaudenzi

Sara Spelta

Giancarlo Sborgia

Maria Poddi

Alessandra Micera

Roberto Sgrulletta

Marco Coassin

Antonio Di Zazzo

Affiliations

Soon will be listed here.

Abstract

Background: Nowadays, the continuous increase in air pollution has significantly changed air quality, leading to the onset of the so-called urban syndrome (US), an allergic-like conjunctivitis triggered by pollutants. These patients are characterized by persistent dysregulation of ocular surface para-inflammation, causing chronic low-grade inflammation and ocular discomfort, with significant consequences for occupational health and job productivity prospects. This study aims to investigate the effects of topical glycerophosphoinositol (GPI) eye drops on the signs and symptoms of US.

Methods: A multicenter prospective open interventional study was performed. Patients affected by US, enrolled from occupational medicine clinics, were treated with eye drops containing 0.001% GPI in 0.2% HA vehicle three times a day. Ocular surface disease index (OSDI), tear break-up time (T-BUT), Schirmer test, Oxford score, hyperemia and ocular surface symptoms were recorded at patient enrolment (T0), after 1 week (T1) and after 1 month (T2) of treatment.

Results: A total of 113 consecutive patients (226 eyes) were included. OSDI score displayed a significant improvement after one week (T0: 39.9 ± 19, T1: 20.8 ± 17.9, T2: 18.4 ± 15.6, < 0.0001); T-BUT (T0: 5.2 ± 2, T1: 7.7 ± 2.2, T2: 9.7 ± 1.8, < 0.0001) and Schirmer Test (T0: 6.6 ± 2.4, T1: 9.7 ± 2.7, T2: 12.6 ± 2.6, < 0.0001) progressively improved from T0 to T2.

Conclusions: trice-daily topic instillation of 0.001% GPI in 0.02% HA vehicle resulted an effective and well tolerated treatment in US patients.

Citing Articles

Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence.

Iqbal S, Ramini A, Kaja S Ocul Surf. 2024; 35:100-116.

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One Soul and Several Faces of Evaporative Dry Eye Disease.

Di Zazzo A, Barabino S, Fasciani R, Aragona P, Giannaccare G, Villani E J Clin Med. 2024; 13(5).

PMID: 38592038 PMC: 10932174. DOI: 10.3390/jcm13051220.

Promising High-Tech Devices in Dry Eye Disease Diagnosis.

De Luca A, Ferraro A, De Gregorio C, Laborante M, Coassin M, Sgrulletta R Life (Basel). 2023; 13(7).

PMID: 37511800 PMC: 10381352. DOI: 10.3390/life13071425.

Effects of air pollution on myopia: an update on clinical evidence and biological mechanisms.

Yuan T, Zou H Environ Sci Pollut Res Int. 2022; 29(47):70674-70685.

PMID: 36031679 PMC: 9515022. DOI: 10.1007/s11356-022-22764-9.

Pathogenesis of the Homeostatic Failure of Ocular Surface as Morpho-Functional Unit.

Di Zazzo A J Clin Med. 2022; 11(16).

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