Evasion of the Host Immune Response by Betaherpesviruses

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jul 24

PMID 34299120

Citations 9

Authors

Daniel G Sausen

Kirstin M Reed

Maimoona S Bhutta

Elisa S Gallo

Ronen Borenstein

Affiliations

Soon will be listed here.

Abstract

The human immune system boasts a diverse array of strategies for recognizing and eradicating invading pathogens. Human betaherpesviruses, a highly prevalent subfamily of viruses, include human cytomegalovirus (HCMV), human herpesvirus (HHV) 6A, HHV-6B, and HHV-7. These viruses have evolved numerous mechanisms for evading the host response. In this review, we will highlight the complex interplay between betaherpesviruses and the human immune response, focusing on protein function. We will explore methods by which the immune system first responds to betaherpesvirus infection as well as mechanisms by which viruses subvert normal cellular functions to evade the immune system and facilitate viral latency, persistence, and reactivation. Lastly, we will briefly discuss recent advances in vaccine technology targeting betaherpesviruses. This review aims to further elucidate the dynamic interactions between betaherpesviruses and the human immune system.

Citing Articles

Novel betaherpesviruses and gammaherpesviruses in bats from central China.

Duan S, Li Z, Zhang X, Yu X Sci Rep. 2024; 14(1):10651.

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Mechanisms of T cell evasion by Epstein-Barr virus and implications for tumor survival.

Sausen D, Poirier M, Spiers L, Smith E Front Immunol. 2024; 14:1289313.

PMID: 38179040 PMC: 10764432. DOI: 10.3389/fimmu.2023.1289313.

Hepatitis B and Hepatitis D Viruses: A Comprehensive Update with an Immunological Focus.

Sausen D, Shechter O, Bietsch W, Shi Z, Miller S, Gallo E Int J Mol Sci. 2022; 23(24).

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Infections and immune dysregulation in ataxia-telangiectasia children with hyper-IgM and non-hyper-IgM phenotypes: A single-center experience.

Szczawinska-Poplonyk A, Tapolska-Jozwiak K, Schwartzmann E, Pietrucha B Front Pediatr. 2022; 10:972952.

PMID: 36340711 PMC: 9631935. DOI: 10.3389/fped.2022.972952.

Restructured membrane contacts rewire organelles for human cytomegalovirus infection.

Cook K, Tsopurashvili E, Needham J, Thompson S, Cristea I Nat Commun. 2022; 13(1):4720.

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