Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jul 24

PMID 34299116

Citations 15

Authors

Benjamin Leyton

Juliana Nunes Ramos

Paulo Victor Pereira Baio

Joao Flavio Carneiro Veras

Cassius Souza

Andreas Burkovski

Ana Luiza Mattos-Guaraldi

Veronica Viana Vieira

Michel Abanto Marin

Affiliations

Soon will be listed here.

Abstract

, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in . This review updates global information related to antimicrobial resistance found in and highlights the essential genomic aspects in its persistence and dissemination. The resistome of comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.

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