Basal Ganglia-orbitofrontal Circuits Are Associated with Prospective Memory Deficits in Wilson's Disease

Overview

Journal Brain Imaging Behav

Publisher Springer

Specialties Neurology
Psychology
Radiology
Social Sciences

Date 2021 Jul 23

PMID 34297310

Citations 5

Authors

Sheng Hu

Chunsheng Xu

Yi Wang

Ting Dong

Hongli Wu

Anqin Wang

Chuanfu Li

Bensheng Qiu

Affiliations

Soon will be listed here.

Abstract

Degenerative changes in the basal ganglia (BG) are thought to contribute to neurological symptoms in Wilson's disease (WD). However, very little is known about whether and how the BG have an influence on prospective memory (PM) by interacting with the cerebral cortex. Here, we employed structural magnetic resonance imaging to systematically examine the effect of volume atrophy of BG on cortical thickness and to evaluate the relationships between cortical thickness of regions associated with BG atrophy and PM performance in WD. Cortical thickness atrophy in the left temporal pole and medial frontal gyrus are not related to degenerative changes in BG. Cortical thickness in the left superior frontal gyrus and right orbitofrontal gyrus (ORB) have stronger correlations with volume atrophy of the left accumbens, pallidum, and putamen in WD when compared with healthy controls. Furthermore, the cortical thickness of the right ORB is not only significantly correlated with PM performance but can also distinguish the severity of PM impairment in WD. Additionally, the middle cingulate cortex was related to volume atrophy of the accumbens, and its cortical thickness has a significant positive correlation with event-based PM. Together, these findings highlight that BG-orbitofrontal circuits may serve as neural biomarkers of PM and provide implications for the neural mechanisms underlying cognitive impairment in WD.

Citing Articles

Structural lesions and transcriptomic specializations shape gradient perturbations in Wilson disease.

Hu S, Li C, Wang Y, Wei T, Wang X, Dong T Brain Commun. 2024; 6(5):fcae329.

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Radiomic and clinical nomogram for cognitive impairment prediction in Wilson's disease.

Tian L, Dong T, Hu S, Zhao C, Yu G, Hu H Front Neurol. 2023; 14:1131968.

PMID: 37188313 PMC: 10177658. DOI: 10.3389/fneur.2023.1131968.

Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson's disease: an automated fiber quantification tractography study.

Wu Y, Hu S, Wang Y, Dong T, Wu H, Wang A Brain Imaging Behav. 2023; 17(2):200-212.

PMID: 36690883 DOI: 10.1007/s11682-022-00753-3.

Dysfunction of the Lenticular Nucleus Is Associated with Dystonia in Wilson's Disease.

Yang Y, Wei T, Yang W, Hu S, Jiang H, Dong W Brain Sci. 2023; 13(1).

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Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease.

Shribman S, Burrows M, Convery R, Bocchetta M, Sudre C, Acosta-Cabronero J Mov Disord. 2022; 37(8):1728-1738.

PMID: 35723521 PMC: 9542291. DOI: 10.1002/mds.29123.

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