Interplay Between Hypoxia and Inflammation Contributes to the Progression and Severity of Respiratory Viral Diseases

Overview

Journal Mol Aspects Med

Specialties Biochemistry
Molecular Biology

Date 2021 Jul 23

PMID 34294412

Citations 14

Authors

Sulagna Bhattacharya

Sakshi Agarwal

Nishith M Shrimali

Prasenjit Guchhait

Affiliations

Soon will be listed here.

Abstract

History of pandemics is dominated by viral infections and specifically respiratory viral diseases like influenza and COVID-19. Lower respiratory tract infection is the fourth leading cause of death worldwide. Crosstalk between resultant inflammation and hypoxic microenvironment may impair ventilatory response of lungs. This reduces arterial partial pressure of oxygen, termed as hypoxemia, which is observed in a section of patients with respiratory virus infections including SARS-CoV-2 (COVID-19). In this review, we describe the interplay between inflammation and hypoxic microenvironment in respiratory viral infection and its contribution to disease pathogenesis.

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References

Vijgen L, Keyaerts E, Moes E, Thoelen I, Wollants E, Lemey P . Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. J Virol. 2005; 79(3):1595-604. PMC: 544107. DOI: 10.1128/JVI.79.3.1595-1604.2005. View

Wu Z, McGoogan J . Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-1242. DOI: 10.1001/jama.2020.2648. View

Cameron M, Ran L, Xu L, Danesh A, Bermejo-Martin J, Cameron C . Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J Virol. 2007; 81(16):8692-706. PMC: 1951379. DOI: 10.1128/JVI.00527-07. View

Ojo A, Balogun S, Williams O, Ojo O . Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies. Pulm Med. 2020; 2020:6175964. PMC: 7439160. DOI: 10.1155/2020/6175964. View

Ostergaard L . SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation. Physiol Rep. 2021; 9(3):e14726. PMC: 7849453. DOI: 10.14814/phy2.14726. View

Esper F, Weibel C, Ferguson D, Landry M, Kahn J . Coronavirus HKU1 infection in the United States. Emerg Infect Dis. 2006; 12(5):775-9. PMC: 3374449. DOI: 10.3201/eid1205.051316. View

Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H . Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020; 130(5):2620-2629. PMC: 7190990. DOI: 10.1172/JCI137244. View

Schlie K, Westerback A, DeVorkin L, Hughson L, Brandon J, MacPherson S . Survival of effector CD8+ T cells during influenza infection is dependent on autophagy. J Immunol. 2015; 194(9):4277-86. DOI: 10.4049/jimmunol.1402571. View

Liu Y, Xiang D, Zhang H, Yao H, Wang Y . Hypoxia-Inducible Factor-1: A Potential Target to Treat Acute Lung Injury. Oxid Med Cell Longev. 2020; 2020:8871476. PMC: 7685819. DOI: 10.1155/2020/8871476. View

10.

Plemper R, Lakdawala A, Gernert K, Snyder J, Compans R . Structural features of paramyxovirus F protein required for fusion initiation. Biochemistry. 2003; 42(22):6645-55. DOI: 10.1021/bi034385k. View

11.

Johnstone J, Majumdar S, Fox J, Marrie T . Human metapneumovirus pneumonia in adults: results of a prospective study. Clin Infect Dis. 2008; 46(4):571-4. DOI: 10.1086/526776. View

12.

Dimitrov D . Virus entry: molecular mechanisms and biomedical applications. Nat Rev Microbiol. 2004; 2(2):109-22. PMC: 7097642. DOI: 10.1038/nrmicro817. View

13.

Branche A, Falsey A . Parainfluenza Virus Infection. Semin Respir Crit Care Med. 2016; 37(4):538-54. PMC: 7171724. DOI: 10.1055/s-0036-1584798. View

14.

Papadopoulos N, Bates P, Bardin P, Papi A, Leir S, Fraenkel D . Rhinoviruses infect the lower airways. J Infect Dis. 2000; 181(6):1875-84. DOI: 10.1086/315513. View

15.

Kelly J, Busse W . Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immunol. 2008; 122(4):671-682. PMC: 3927944. DOI: 10.1016/j.jaci.2008.08.013. View

16.

Frickmann H, Jungblut S, Hirche T, Gross U, Kuhns M, Zautner A . The influence of virus infections on the course of COPD. Eur J Microbiol Immunol (Bp). 2014; 2(3):176-85. PMC: 3962752. DOI: 10.1556/EuJMI.2.2012.3.2. View

17.

Allander T, Tammi M, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B . Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A. 2005; 102(36):12891-6. PMC: 1200281. DOI: 10.1073/pnas.0504666102. View

18.

Perez-Padilla R, Garcia-Sancho C, Fernandez R, Franco-Marina F, Lopez-Gatell H, Bojorquez I . The impact of altitude on hospitalization and hospital mortality from pandemic 2009 influenza A (H1N1) virus pneumonia in Mexico. Salud Publica Mex. 2013; 55(1):92-5. DOI: 10.1590/s0036-36342013000100013. View

19.

Loo Y, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L . Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol. 2007; 82(1):335-45. PMC: 2224404. DOI: 10.1128/JVI.01080-07. View

20.

Nieto-Torres J, DeDiego M, Verdia-Baguena C, Jimenez-Guardeno J, Regla-Nava J, Fernandez-Delgado R . Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis. PLoS Pathog. 2014; 10(5):e1004077. PMC: 4006877. DOI: 10.1371/journal.ppat.1004077. View