Overweight and Obesity in Type 1 Diabetes is Not Associated with Higher Ghrelin Concentrations

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2021 Jul 23

PMID 34294136

Citations 1

Authors

Behiye Ozcan

Patric J D Delhanty

Martin Huisman

Jenny A Visser

Sebastian J Neggers

Aart Jan van der Lely

Affiliations

Soon will be listed here.

Abstract

Background: Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This study assessed the relationship between AG and UAG levels and body composition in patients with type 1 diabetes.

Methods: We selected eighteen patients with type 1 diabetes and divided them into two groups: non-obese (BMI < 25 kg/m) and overweight (BMI ≥ 25 kg/m). Demographics, parameters of body composition and serum parameters including AG and UAG, were assessed.

Results: The patients with a BMI ≥ 25 kg/m were older and had a longer duration of diabetes. AG and UAG levels were not significantly different between non-obese and overweight groups (mean AG non-obese ± SD: 44.5 ± 29.4 pg/ml and mean UAG non-obese 42.4 ± 20.7 pg/ml vs mean AG overweight ± SD: 46.1 ± 29.6 pg/ml and mean UAG overweight 47.2 ± 18.2 pg/ml). AG/UAG ratios did not discriminate between these groups. There was a positive association of insuline dose/kg bodyweight with BMI (r = 0.45, p = 0.002).

Conclusions: Surprisingly, unlike non-diabetics and in T2D, we did not observe a difference in plasma levels of AG and UAG between normal weight and overweight adult type 1 diabetics. However, we did observe a positive correlation between BMI and insuline dose/kg bodyweight, suggesting that exogenous insulin is more important than the ghrelin system in the development of obesity in type 1 diabetes.

Citing Articles

Overweight/obesity in adolescents with type 1 diabetes belonging to an admixed population. A Brazilian multicenter study.

Gomes M, Conte D, Drummond K, Mallmann F, Pinheiro A, Leal F Diabetol Metab Syndr. 2022; 14(1):1.

PMID: 34983637 PMC: 8725457. DOI: 10.1186/s13098-021-00759-9.

References

Blatnik M, Soderstrom C . A practical guide for the stabilization of acylghrelin in human blood collections. Clin Endocrinol (Oxf). 2010; 74(3):325-31. DOI: 10.1111/j.1365-2265.2010.03916.x. View

Ueno H, Shiiya T, Mizuta M, Mondal S, Nakazato M . Plasma ghrelin concentrations in different clinical stages of diabetic complications and glycemic control in Japanese diabetics. Endocr J. 2007; 54(6):895-902. DOI: 10.1507/endocrj.k07-007. View

Soriano-Guillen L, Barrios V, Martos G, Chowen J, Campos-Barros A, Argente J . Effect of oral glucose administration on ghrelin levels in obese children. Eur J Endocrinol. 2004; 151(1):119-21. DOI: 10.1530/eje.0.1510119. View

Ishii S, Kamegai J, Tamura H, Shimizu T, Sugihara H, Oikawa S . Role of ghrelin in streptozotocin-induced diabetic hyperphagia. Endocrinology. 2002; 143(12):4934-7. DOI: 10.1210/en.2002-220612. View

Masaoka T, Suzuki H, Hosoda H, Ota T, Minegishi Y, Nagata H . Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. FEBS Lett. 2003; 541(1-3):64-8. DOI: 10.1016/s0014-5793(03)00306-5. View

Conway B, Miller R, Costacou T, Fried L, Kelsey S, Evans R . Temporal patterns in overweight and obesity in Type 1 diabetes. Diabet Med. 2010; 27(4):398-404. PMC: 3129711. DOI: 10.1111/j.1464-5491.2010.02956.x. View

Shimizu Y, Nagaya N, Isobe T, Imazu M, Okumura H, Hosoda H . Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res. 2003; 9(2):774-8. View

Takagi K, Legrand R, Asakawa A, Amitani H, Francois M, Tennoune N . Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans. Nat Commun. 2013; 4:2685. PMC: 3826639. DOI: 10.1038/ncomms3685. View

Gelling R, Overduin J, Morrison C, Morton G, Frayo R, Cummings D . Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding. Endocrinology. 2004; 145(10):4575-82. DOI: 10.1210/en.2004-0605. View

10.

Bideci A, Camurdan M, Cinaz P, Demirel F . Ghrelin, IGF-I and IGFBP-3 levels in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2006; 18(12):1433-9. DOI: 10.1515/jpem.2005.18.12.1433. View

11.

Irako T, Akamizu T, Hosoda H, Iwakura H, Ariyasu H, Tojo K . Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats. Diabetologia. 2006; 49(6):1264-73. DOI: 10.1007/s00125-006-0226-3. View

12.

Kadoglou N, Sailer N, Kapelouzou A, Lampropoulos S, Vitta I, Kostakis A . Effects of atorvastatin on apelin, visfatin (nampt), ghrelin and early carotid atherosclerosis in patients with type 2 diabetes. Acta Diabetol. 2011; 49(4):269-76. DOI: 10.1007/s00592-011-0310-0. View

13.

Abdemur A, Slone J, Berho M, Gianos M, Szomstein S, Rosenthal R . Morphology, localization, and patterns of ghrelin-producing cells in stomachs of a morbidly obese population. Surg Laparosc Endosc Percutan Tech. 2014; 24(2):122-6. DOI: 10.1097/SLE.0b013e318290167a. View

14.

Polkowska A, Szczepaniak I, Bossowski A . Assessment of Serum Concentrations of Ghrelin, Obestatin, Omentin-1, and Apelin in Children with Type 1 Diabetes. Biomed Res Int. 2016; 2016:8379294. PMC: 4745415. DOI: 10.1155/2016/8379294. View

15.

Marchesini G, Bianchi G, Lucidi P, Villanova N, Zoli M, De Feo P . Plasma ghrelin concentrations, food intake, and anorexia in liver failure. J Clin Endocrinol Metab. 2004; 89(5):2136-41. DOI: 10.1210/jc.2003-031771. View

16.

Lugari R, DellAnna C, Ugolotti D, Dei Cas A, Barilli A, Zandomeneghi R . Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes. Horm Metab Res. 2000; 32(10):424-8. DOI: 10.1055/s-2007-978665. View

17.

Nass R, Farhy L, Liu J, Pezzoli S, Johnson M, Gaylinn B . Age-dependent decline in acyl-ghrelin concentrations and reduced association of acyl-ghrelin and growth hormone in healthy older adults. J Clin Endocrinol Metab. 2013; 99(2):602-8. PMC: 3913814. DOI: 10.1210/jc.2013-3158. View

18.

Yi C, Heppner K, Kirchner H, Tong J, Bielohuby M, Gaylinn B . The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS One. 2012; 7(2):e32100. PMC: 3283719. DOI: 10.1371/journal.pone.0032100. View

19.

van der Lely A, Tschop M, Heiman M, Ghigo E . Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004; 25(3):426-57. DOI: 10.1210/er.2002-0029. View

20.

Park S, Jiang H, Zhang H, Smith R . Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release. Proc Natl Acad Sci U S A. 2012; 109(46):19003-8. PMC: 3503195. DOI: 10.1073/pnas.1209590109. View