Role of Flavonoids in the Treatment of Iron Overload

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Jul 22

PMID 34291050

Citations 27

Authors

Xiaomin Wang

Ye Li

Li Han

Jie Li

Cun Liu

Changgang Sun

Affiliations

Soon will be listed here.

Abstract

Iron overload, a high risk factor for many diseases, is seen in almost all human chronic and common diseases. Iron chelating agents are often used for treatment but, at present, most of these have a narrow scope of application, obvious side effects, and other disadvantages. Recent studies have shown that flavonoids can affect iron status, reduce iron deposition, and inhibit the lipid peroxidation process caused by iron overload. Therefore, flavonoids with iron chelating and antioxidant activities may become potential complementary therapies. In this study, we not only reviewed the research progress of iron overload and the regulation mechanism of flavonoids, but also studied the structural basis and potential mechanism of their function. In addition, the advantages and disadvantages of flavonoids as plant iron chelating agents are discussed to provide a foundation for the prevention and treatment of iron homeostasis disorders using flavonoids.

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