Hepatoprotective Effects of Against Carbon Tetrachloride-Induced Acute Liver Injury in Rats

Overview

Journal Dose Response

Publisher Sage Publications

Date 2021 Jul 22

PMID 34290575

Authors

Jie Li

Dan Song

Bintao Zhang

Jinwei Guo

Wenping Li

Xiaoying Zhang

Qin Zhao

Affiliations

Soon will be listed here.

Abstract

Purpose: To determine the hepatoprotective mechanisms of in rats with acute liver injury induced by carbon tetrachloride (CCl).

Methods: Rats were intragastrically administered twice a day for 14 consecutive days and were intraperitoneally challenged with CCl. Alanine aminotransferase and aspartate aminotransferase were measured to indicate liver injury. Malondialdehyde antioxidant enzyme activity and tumor necrosis factor-alpha and interleukin 6 secretion were measured as liver injury indicators. Histopathological tests were conducted to determine whether ameliorated liver injury.

Results: CCl-induced liver injury led to significant increases in liver injury biochemical indicators transaminase and malondialdehyde activities. pretreatments inhibited these increases. Pathological sections in pretreated samples exhibited reduced vacuole formation, neutrophil infiltration, and necrosis.

Conclusion: increases the antioxidant capacity of the liver and maintains hepatocyte function in the face of CCl-induced injury.

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