Biomarkers of Inflammation and Oxidative Stress Among Adult Former Smoker, Current E-Cigarette Users-Results from Wave 1 PATH Study

Overview

Journal Cancer Epidemiol Biomarkers Prev

Specialties Biochemistry
Oncology
Public Health

Date 2021 Jul 22

PMID 34289969

Citations 10

Authors

Carol H Christensen

Joanne T Chang

Brian L Rostron

Hoda T Hammad

Dana M van Bemmel

Arseima Y Del Valle-Pinero

Baoguang Wang

Elena V Mishina

Lisa M Faulcon

Ana DePina

LaNissa Brown-Baker

Heather L Kimmel

Elizabeth Lambert

Benjamin C Blount

Huber W Vesper

Lanqing Wang

Maciej L Goniewicz

Andrew Hyland

Mark J Travers

Dorothy K Hatsukami

Raymond Niaura

K Michael Cummings

Kristie A Taylor

Kathryn C Edwards

Nicolette Borek

Bridget K Ambrose

Cindy M Chang

Affiliations

Soon will be listed here.

Abstract

Background: Former smokers who currently use e-cigarettes have lower concentrations of biomarkers of tobacco toxicant exposure than current smokers. It is unclear whether tobacco toxicant exposure reductions may lead to health risk reductions.

Methods: We compared inflammatory biomarkers (high-sensitivity C-reactive protein, IL6, fibrinogen, soluble intercellular adhesion molecule-1) and an oxidative stress marker (F2-isoprostane) among 3,712 adult participants in Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study by tobacco user groups: dual users of cigarettes and e-cigarettes; former smokers who currently use e-cigarettes-only; current cigarette-only smokers; former smokers who do not currently use any tobacco; and never tobacco users. We calculated geometric means (GM) and estimated adjusted GM ratios (GMR).

Results: Dual users experienced greater concentration of F2-isoprostane than current cigarette-only smokers [GMR 1.09 (95% confidence interval, CI, 1.03-1.15)]. Biomarkers were similar between former smokers who currently use e-cigarettes and both former smokers who do not use any tobacco and never tobacco users, but among these groups most biomarkers were lower than those of current cigarette-only smokers. The concentration of F2-isoprostane decreased by time since smoking cessation among both exclusive e-cigarette users ( = 0.03) and former smokers who do not currently use any tobacco ( = 0.0001).

Conclusions: Dual users have greater concentration of F2-isoprostane than smokers. Exclusive e-cigarette users have biomarker concentrations that are similar to those of former smokers who do not currently use tobacco, and lower than those of exclusive cigarette smokers.

Impact: This study contributes to an understanding of the health effects of e-cigarettes.

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