Human Models for COVID-19 Research

Overview

Journal J Physiol

Specialty Physiology

Date 2021 Jul 21

PMID 34287894

Citations 6

Authors

Maximillian N J Woodall

Tereza Masonou

Katie-Marie Case

Claire M Smith

Affiliations

Soon will be listed here.

Abstract

Currently, therapeutics for COVID-19 are limited. To overcome this, it is important that we use physiologically relevant models to reproduce the pathology of infection and evaluate the efficacy of antiviral drugs. Models of airway infection, including the use of a human infection challenge model or well-defined, disease relevant in vitro systems can help determine the key components that perpetuate the severity of the disease. Here, we briefly review the human models that are currently being used in COVID-19 research and drug development.

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