Preparation and Characterization of 2-hydroxyethyl Starch Microparticles for Co-delivery of Multiple Bioactive Agents

Overview

Journal Drug Deliv

Specialty Pharmacology

Date 2021 Jul 21

PMID 34286634

Citations 20

Authors

Sreekanth Reddy Obireddy

Wing-Fu Lai

Affiliations

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Abstract

The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents. The obtained microparticles are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. By using ofloxacin and ketoprofen as drug models, the release sustainability of the microparticles is examined at pH 1.2, 5.4, and 6.8 at 37 °C, with Fickian diffusion being found to be the major mechanism controlling the kinetics of drug release. Upon being loaded with the drug models, the microparticles show high efficiency in acting against and . The results suggest that our reported microparticles warrant further development for applications in which co-administration of multiple bioactive agents is required.

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