Functional Hydrogels for Diabetic Wound Management

Overview

Journal APL Bioeng

Date 2021 Jul 21

PMID 34286170

Citations 31

Authors

Daqian Gao

Yidan Zhang

Daniel T Bowers

Wanjun Liu

Minglin Ma

Affiliations

Soon will be listed here.

Abstract

Diabetic wounds often have a slow healing process and become easily infected owing to hyperglycemia in wound beds. Once planktonic bacterial cells develop into biofilms, the diabetic wound becomes more resistant to treatment. Although it remains challenging to accelerate healing in a diabetic wound due to complex pathology, including bacterial infection, high reactive oxygen species, chronic inflammation, and impaired angiogenesis, the development of multifunctional hydrogels is a promising strategy. Multiple functions, including antibacterial, pro-angiogenesis, and overall pro-healing, are high priorities. Here, design strategies, mechanisms of action, performance, and application of functional hydrogels are systematically discussed. The unique properties of hydrogels, including bactericidal and wound healing promotive effects, are reviewed. Considering the clinical need, stimuli-responsive and multifunctional hydrogels that can accelerate diabetic wound healing are likely to form an important part of future diabetic wound management.

Citing Articles

Nanomachine Networks: Functional All-Enzyme Hydrogels from Photochemical Cross-Linking of Glucose Oxidase.

Laurent H, Brockwell D, Dougan L Biomacromolecules. 2025; 26(2):1195-1206.

PMID: 39847607 PMC: 11815861. DOI: 10.1021/acs.biomac.4c01519.

Immunomodulation of Macrophages in Diabetic Wound Individuals by Structurally Diverse Bioactive Phytochemicals.

Adhikary K, Maity S, Sadhukhan I, Sarkar R, Ganguly K, Barman S Pharmaceuticals (Basel). 2024; 17(10).

PMID: 39458935 PMC: 11510503. DOI: 10.3390/ph17101294.

Advances in Smart-Response Hydrogels for Skin Wound Repair.

Fan Y, Wang H, Wang C, Xing Y, Liu S, Feng L Polymers (Basel). 2024; 16(19).

PMID: 39408528 PMC: 11479249. DOI: 10.3390/polym16192818.

Advances in nucleic acid delivery strategies for diabetic wound therapy.

Sarthi S, Bhardwaj H, Jangde R J Clin Transl Endocrinol. 2024; 37:100366.

PMID: 39286540 PMC: 11404062. DOI: 10.1016/j.jcte.2024.100366.

Advancements in diabetic foot ulcer research: Focus on mesenchymal stem cells and their exosomes.

Wu S, Zhou Z, Li Y, Jiang J Heliyon. 2024; 10(17):e37031.

PMID: 39286219 PMC: 11403009. DOI: 10.1016/j.heliyon.2024.e37031.

References

Schafer M, Werner S . Oxidative stress in normal and impaired wound repair. Pharmacol Res. 2008; 58(2):165-71. DOI: 10.1016/j.phrs.2008.06.004. View

Liu Q, Singh A, Liu L . Amino acid-based zwitterionic poly(serine methacrylate) as an antifouling material. Biomacromolecules. 2012; 14(1):226-31. DOI: 10.1021/bm301646y. View

Evelhoch S . Biofilm and Chronic Nonhealing Wound Infections. Surg Clin North Am. 2020; 100(4):727-732. DOI: 10.1016/j.suc.2020.05.004. View

Gao S, Chang C, Li J, Li Y, Niu X, Zhang D . Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis. Drug Deliv. 2018; 25(1):1779-1789. PMC: 6201774. DOI: 10.1080/10717544.2018.1513608. View

He H, Xiao Z, Zhou Y, Chen A, Xuan X, Li Y . Zwitterionic poly(sulfobetaine methacrylate) hydrogels with optimal mechanical properties for improving wound healing in vivo. J Mater Chem B. 2020; 7(10):1697-1707. DOI: 10.1039/c8tb02590h. View

Xu H, Lv F, Zhang Y, Yi Z, Ke Q, Wu C . Hierarchically micro-patterned nanofibrous scaffolds with a nanosized bio-glass surface for accelerating wound healing. Nanoscale. 2015; 7(44):18446-52. DOI: 10.1039/c5nr04802h. View

Rahman M, Kim S, Kim S, Seol S, Kim J . Characterization of induced Staphylococcus aureus bacteriophage SAP-26 and its anti-biofilm activity with rifampicin. Biofouling. 2011; 27(10):1087-93. DOI: 10.1080/08927014.2011.631169. View

Winter G . EFFECT OF AIR EXPOSURE AND OCCLUSION ON EXPERIMENTAL HUMAN SKIN WOUNDS. Nature. 1963; 200:378-9. DOI: 10.1038/200378a0. View

Los M, Golec P, Los J, Weglewska-Jurkiewicz A, Czyz A, Wegrzyn A . Effective inhibition of lytic development of bacteriophages lambda, P1 and T4 by starvation of their host, Escherichia coli. BMC Biotechnol. 2007; 7:13. PMC: 1820593. DOI: 10.1186/1472-6750-7-13. View

10.

Wu T, Huang J, Jiang Y, Hu Y, Ye X, Liu D . Formation of hydrogels based on chitosan/alginate for the delivery of lysozyme and their antibacterial activity. Food Chem. 2017; 240:361-369. DOI: 10.1016/j.foodchem.2017.07.052. View

11.

Peng L, Chang L, Si M, Lin J, Wei Y, Wang S . Hydrogel-Coated Dental Device with Adhesion-Inhibiting and Colony-Suppressing Properties. ACS Appl Mater Interfaces. 2020; 12(8):9718-9725. DOI: 10.1021/acsami.9b19873. View

12.

Nilforoushzadeh M, Sisakht M, Amirkhani M, Seifalian A, Banafshe H, Verdi J . Engineered skin graft with stromal vascular fraction cells encapsulated in fibrin-collagen hydrogel: A clinical study for diabetic wound healing. J Tissue Eng Regen Med. 2019; 14(3):424-440. DOI: 10.1002/term.3003. View

13.

Hamad B . The antibiotics market. Nat Rev Drug Discov. 2010; 9(9):675-6. DOI: 10.1038/nrd3267. View

14.

Su Y, Mainardi V, Wang H, McCarthy A, Zhang Y, Chen S . Dissolvable Microneedles Coupled with Nanofiber Dressings Eradicate Biofilms Effectively Delivering a Database-Designed Antimicrobial Peptide. ACS Nano. 2020; 14(9):11775-11786. PMC: 7673654. DOI: 10.1021/acsnano.0c04527. View

15.

Dunnill C, Patton T, Brennan J, Barrett J, Dryden M, Cooke J . Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process. Int Wound J. 2015; 14(1):89-96. PMC: 7950185. DOI: 10.1111/iwj.12557. View

16.

Gao D, Zhou X, Gao Z, Shi X, Wang Z, Wang Y . Preparation and Characterization of Silver Sulfadiazine-Loaded Polyvinyl Alcohol Hydrogels as an Antibacterial Wound Dressing. J Pharm Sci. 2018; 107(9):2377-2384. DOI: 10.1016/j.xphs.2018.04.027. View

17.

Reiber G . The epidemiology of diabetic foot problems. Diabet Med. 1996; 13 Suppl 1:S6-11. View

18.

Zhu Y, Hoshi R, Chen S, Yi J, Duan C, Galiano R . Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes. J Control Release. 2016; 238:114-122. DOI: 10.1016/j.jconrel.2016.07.043. View

19.

Ahluwalia A, Tarnawski A . Critical role of hypoxia sensor--HIF-1α in VEGF gene activation. Implications for angiogenesis and tissue injury healing. Curr Med Chem. 2012; 19(1):90-7. DOI: 10.2174/092986712803413944. View

20.

Carmen J, Roeder B, Nelson J, Ogilvie R, Robison R, Schaalje G . Treatment of biofilm infections on implants with low-frequency ultrasound and antibiotics. Am J Infect Control. 2005; 33(2):78-82. PMC: 1361257. DOI: 10.1016/j.ajic.2004.08.002. View