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National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

Abstract

In the Netherlands, the model-based approach is used to identify patients with head and neck cancer who may benefit most from proton therapy in terms of prevention of late radiation-induced side effects in comparison with photon therapy. To this purpose, a National Indication Protocol Proton therapy for Head and Neck Cancer patients (NIPP-HNC) was developed, which has been approved by the health care authorities. When patients qualify according to the guidelines of the NIPP-HNC, proton therapy is fully reimbursed. This article describes the procedures that were followed to develop this NIPP-HNC and provides all necessary information to introduce model-based selection for patients with head and neck cancer into routine clinical practice.

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References
1.
Christianen M, van der Schaaf A, van der Laan H, Verdonck-de Leeuw I, Doornaert P, Chouvalova O . Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach. Radiother Oncol. 2015; 118(2):298-303. DOI: 10.1016/j.radonc.2015.11.009. View

2.
Langendijk J, Lambin P, De Ruysscher D, Widder J, Bos M, Verheij M . Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach. Radiother Oncol. 2013; 107(3):267-73. DOI: 10.1016/j.radonc.2013.05.007. View

3.
Lee T, Fang F . Quantitative analysis of normal tissue effects in the clinic (QUANTEC) guideline validation using quality of life questionnaire datasets for parotid gland constraints to avoid causing xerostomia during head-and-neck radiotherapy. Radiother Oncol. 2013; 106(3):352-8. DOI: 10.1016/j.radonc.2012.11.013. View

4.
Dean J, Welsh L, Wong K, Aleksic A, Dunne E, Islam M . Normal Tissue Complication Probability (NTCP) Modelling of Severe Acute Mucositis using a Novel Oral Mucosal Surface Organ at Risk. Clin Oncol (R Coll Radiol). 2017; 29(4):263-273. PMC: 6175048. DOI: 10.1016/j.clon.2016.12.001. View

5.
Mazzola R, Ricchetti F, Fiorentino A, Fersino S, Giaj Levra N, Naccarato S . Dose-volume-related dysphagia after constrictor muscles definition in head and neck cancer intensity-modulated radiation treatment. Br J Radiol. 2014; 87(1044):20140543. PMC: 4243212. DOI: 10.1259/bjr.20140543. View