Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

Overview

Journal Diabetes Metab Syndr Obes

Publisher Dove Medical Press

Specialty Endocrinology

Date 2021 Jul 21

PMID 34285528

Citations 8

Authors

Chen-Xing Qi

Xin Huang

Yan Tong

Yin Shen

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of the study was to find the differences in intrinsic functional connectivity (FC) patterns of the primary visual area (V1) among diabetic retinopathy (DR), diabetes mellitus (DM), and healthy controls (HCs) applying resting-state functional magnetic resonance imaging (rs-fMRI).

Patients And Methods: Thirty-five subjects with DR (18 males and 17 females), 22 DM (10 males and 12 females) and 38 HCs (16 males and 22 females) matched for sex, age, and education underwent rs-fMRI scanning. Seed-based FC analysis was performed to find the alterations in the intrinsic FC patterns of V1 in DR compared with DM and HCs.

Results: The study found that DR patients had a significant lower FC between the bilateral calcarine (CAL)/left lingual gyrus (LING) (BA 17/18) and the left V1, and between the bilateral CAL/left LING (BA 17/18) and the right V1 compared with the HCs. Meanwhile, patients with DR exhibited higher FC strength between the left V1 and the bilateral Caudate/Olfactory/Orbital superior frontal gyrus (OSFG), and between the bilateral Caudate/Olfactory/OSFG (BA 3/4/6) and the right V1. Compared with DM group, patients with DR showed increased FC strength between the right CAL (BA 17/18) and the right V1. DM group exhibited lower FC strength between the left fusiform and the left V1, and between the bilateral CAL and the right V1 when compared with HCs. Moreover, DM group was observed to have higher FC strength between the left superior frontal gyrus and the left V1.

Conclusion: Our findings indicated that DR patients exhibited FC disruptions between V1 and higher visual regions at rest, which may reflect the aberrant information communication in the V1 area of DR individuals. The findings offer important insights into the neuromechanism of vision disorder in DR patients.

Citing Articles

Aberrant Modular Segregation of Brain Networks in Patients with Diabetic Retinopathy.

Li H, Su Y, Huang X Diabetes Metab Syndr Obes. 2024; 17:3239-3248.

PMID: 39234209 PMC: 11372295. DOI: 10.2147/DMSO.S470950.

Exploration of Hippocampal Functional Connectivity Alterations in Patients with High Myopia via Seed-Based Functional Connectivity Analysis.

Wei B, Fu W, Ji Y, Cheng Q, Shu B, Huang Q Clin Ophthalmol. 2023; 17:3443-3451.

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Functional-structural decoupling in visual network is associated with cognitive decline in patients with type 2 diabetes mellitus: evidence from a multimodal MRI analysis.

Ni M, Yu Y, Yang Y, Li Z, Ma T, Xie H Brain Imaging Behav. 2023; 18(1):73-82.

PMID: 37874444 DOI: 10.1007/s11682-023-00801-6.

Abnormal regional spontaneous neural activity and functional connectivity in thyroid-associated ophthalmopathy patients with different activity: a resting-state fMRI study.

Jiang M, Zhang H, Liu Y, Wu S, Qu J, Tang Y Front Neurol. 2023; 14:1199251.

PMID: 37475733 PMC: 10354644. DOI: 10.3389/fneur.2023.1199251.

Exploration of static functional connectivity and dynamic functional connectivity alterations in the primary visual cortex among patients with high myopia seed-based functional connectivity analysis.

Ji Y, Huang S, Cheng Q, Fu W, Zhong P, Chen X Front Neurosci. 2023; 17:1126262.

PMID: 36816124 PMC: 9932907. DOI: 10.3389/fnins.2023.1126262.

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