Indexing Cerebrovascular Health Using Near-infrared Spectroscopy

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jul 21

PMID 34285338

Citations 2

Authors

Rashid Afkhami

Frederick R Walker

Saadallah Ramadan

Rachel Wong

Sarah J Johnson

Affiliations

Soon will be listed here.

Abstract

Near-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking device using a recently proposed pulse relaxation function (PReFx). In this paper, we propose a new NiRS timing index, [Formula: see text], of cerebrovascular health. [Formula: see text] is a novel use of the NiRS technology. [Formula: see text] is motivated by the previously proved relationship of the timing of the reflected wave with vascular resistance and compliance in the context of pressure waveforms. We correlated both [Formula: see text] and PReFx against age, a non-exercise cardiorespiratory fitness (CRF) index, and two existing indices of cerebrovascular health, namely transcranial Doppler (TCD) augmentation index, [Formula: see text], and magnetic resonance imaging (MRI) blood flow pulsatility index, [Formula: see text]. The [Formula: see text] correlations with Age, CRF, [Formula: see text] and [Formula: see text] all are significant, i.e., [Formula: see text] ([Formula: see text]), [Formula: see text] ([Formula: see text]), [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]), respectively. PReFx, however, did not have significant correlations with any of the vascular health factors. The proposed timing index is a reliable indicator of cerebrovascular aging factors in the NiRS waveform.

Citing Articles

Estimation of Respiratory Rate during Biking with a Single Sensor Functional Near-Infrared Spectroscopy (fNIRS) System.

Shahbakhti M, Hakimi N, Horschig J, Floor-Westerdijk M, Claassen J, Colier W Sensors (Basel). 2023; 23(7).

PMID: 37050692 PMC: 10099192. DOI: 10.3390/s23073632.

The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults.

Bliss E, Wong R, Howe P, Mills D Front Aging Neurosci. 2022; 14:892343.

PMID: 35663579 PMC: 9158462. DOI: 10.3389/fnagi.2022.892343.

References

Tan C, Low K, Kong T, Fletcher M, Zimmerman B, Maclin E . Mapping cerebral pulse pressure and arterial compliance over the adult lifespan with optical imaging. PLoS One. 2017; 12(2):e0171305. PMC: 5325189. DOI: 10.1371/journal.pone.0171305. View

Boreham C, Ferreira I, Twisk J, Gallagher A, Savage M, Murray L . Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland Young Hearts Project. Hypertension. 2004; 44(5):721-6. DOI: 10.1161/01.HYP.0000144293.40699.9a. View

Fabiani M, Low K, Tan C, Zimmerman B, Fletcher M, Schneider-Garces N . Taking the pulse of aging: mapping pulse pressure and elasticity in cerebral arteries with optical methods. Psychophysiology. 2014; 51(11):1072-88. PMC: 9906973. DOI: 10.1111/psyp.12288. View

Birnefeld J, Wahlin A, Eklund A, Malm J . Cerebral arterial pulsatility is associated with features of small vessel disease in patients with acute stroke and TIA: a 4D flow MRI study. J Neurol. 2019; 267(3):721-730. PMC: 7035303. DOI: 10.1007/s00415-019-09620-6. View

Mitchell G, van Buchem M, Sigurdsson S, Gotal J, Jonsdottir M, Kjartansson O . Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study. Brain. 2011; 134(Pt 11):3398-407. PMC: 3212721. DOI: 10.1093/brain/awr253. View

Afkhami R, Walker F, Ramadan S, Johnson S . A Dynamic Model of Brain Hemodynamics in Near-Infrared Spectroscopy. IEEE Trans Biomed Eng. 2019; 67(7):2103-2109. DOI: 10.1109/TBME.2019.2954829. View

Sugawara J, Hayashi K, Tanaka H . Distal shift of arterial pressure wave reflection sites with aging. Hypertension. 2010; 56(5):920-5. PMC: 3018759. DOI: 10.1161/HYPERTENSIONAHA.110.160549. View

London G, Pannier B, Safar M . Arterial Stiffness Gradient, Systemic Reflection Coefficient, and Pulsatile Pressure Wave Transmission in Essential Hypertension. Hypertension. 2019; 74(6):1366-1372. DOI: 10.1161/HYPERTENSIONAHA.119.13387. View

Pantoni L . Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010; 9(7):689-701. DOI: 10.1016/S1474-4422(10)70104-6. View

10.

Kohara K, Tabara Y, Oshiumi A, Miyawaki Y, Kobayashi T, Miki T . Radial augmentation index: a useful and easily obtainable parameter for vascular aging. Am J Hypertens. 2005; 18(1 Pt 2):11S-14S. DOI: 10.1016/j.amjhyper.2004.10.010. View

11.

Reisner A, Shaltis P, McCombie D, Asada H . Utility of the photoplethysmogram in circulatory monitoring. Anesthesiology. 2008; 108(5):950-8. DOI: 10.1097/ALN.0b013e31816c89e1. View

12.

Millasseau S, Kelly R, Ritter J, Chowienczyk P . Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clin Sci (Lond). 2002; 103(4):371-7. DOI: 10.1042/cs1030371. View

13.

Li Q, Yang Y, Reis C, Tao T, Li W, Li X . Cerebral Small Vessel Disease. Cell Transplant. 2018; 27(12):1711-1722. PMC: 6300773. DOI: 10.1177/0963689718795148. View

14.

Poels M, Zaccai K, Verwoert G, Vernooij M, Hofman A, van der Lugt A . Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke. 2012; 43(10):2637-42. DOI: 10.1161/STROKEAHA.111.642264. View

15.

Hirata K, Yaginuma T, ORourke M, Kawakami M . Age-related changes in carotid artery flow and pressure pulses: possible implications for cerebral microvascular disease. Stroke. 2006; 37(10):2552-6. DOI: 10.1161/01.STR.0000242289.20381.f4. View

16.

Woodman R, Kingwell B, Beilin L, Hamilton S, Dart A, Watts G . Assessment of central and peripheral arterial stiffness: studies indicating the need to use a combination of techniques. Am J Hypertens. 2005; 18(2 Pt 1):249-60. DOI: 10.1016/j.amjhyper.2004.08.038. View

17.

Jurca R, Jackson A, LaMonte M, Morrow Jr J, Blair S, Wareham N . Assessing cardiorespiratory fitness without performing exercise testing. Am J Prev Med. 2005; 29(3):185-93. DOI: 10.1016/j.amepre.2005.06.004. View

18.

Segers P, Rietzschel E, De Buyzere M, De Bacquer D, Van Bortel L, De Backer G . Assessment of pressure wave reflection: getting the timing right!. Physiol Meas. 2007; 28(9):1045-56. DOI: 10.1088/0967-3334/28/9/006. View

19.

GOSLING R, King D . Arterial assessment by Doppler-shift ultrasound. Proc R Soc Med. 1974; 67(6 Pt 1):447-9. PMC: 1645777. View

20.

Carrera E, Kim D, Castellani G, Zweifel C, Smielewski P, Pickard J . Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects. J Neuroimaging. 2009; 21(2):121-5. DOI: 10.1111/j.1552-6569.2009.00439.x. View