Coronavirus Disease 2019 and the Thyroid - Progress and Perspectives

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Jul 19

PMID 34276567

Citations 29

Authors

Hidefumi Inaba

Toru Aizawa

Affiliations

Soon will be listed here.

Abstract

SARS-CoV-2 infection (COVID-19) is currently a tremendous global health problem. COVID-19 causes considerable damage to a wide range of vital organs most prominently the respiratory system. Recently, clinical evidence for thyroidal insults during and after COVID-19 has been accumulated. As of today, almost all non-neoplastic thyroid diseases, i.e., Graves' disease, Hashimoto's thyroiditis, subacute, painless and postpartum thyroiditis, have been reported as a complication of COVID-19, and causality by the virus has been strongly implicated in all of them. Similar thyroid problems have been reported in the past with the SARS-CoV outbreak in 2002. In this review, we briefly look back at the reported evidence of alteration in thyroid functionality and thyroid diseases associated with SARS-CoV and then proceed to examine the issue with COVID-19 in detail, which is then followed by an in-depth discussion regarding a pathogenetic link between Coronavirus infection and thyroid disease.

Citing Articles

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References

Ippolito S, Dentali F, Tanda M . SARS-CoV-2: a potential trigger for subacute thyroiditis? Insights from a case report. J Endocrinol Invest. 2020; 43(8):1171-1172. PMC: 7266411. DOI: 10.1007/s40618-020-01312-7. View

Martin A, Davies T . T cells and human autoimmune thyroid disease: emerging data show lack of need to invoke suppressor T cell problems. Thyroid. 1992; 2(3):247-61. DOI: 10.1089/thy.1992.2.247. View

Marshall M . COVID's toll on smell and taste: what scientists do and don't know. Nature. 2021; 589(7842):342-343. DOI: 10.1038/d41586-021-00055-6. View

Tozzoli R, Barzilai O, Ram M, Villalta D, Bizzaro N, Sherer Y . Infections and autoimmune thyroid diseases: parallel detection of antibodies against pathogens with proteomic technology. Autoimmun Rev. 2008; 8(2):112-5. DOI: 10.1016/j.autrev.2008.07.013. View

Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J . Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol. 2004; 203(2):622-30. PMC: 7167761. DOI: 10.1002/path.1560. View

Desailloud R, Hober D . Viruses and thyroiditis: an update. Virol J. 2009; 6:5. PMC: 2654877. DOI: 10.1186/1743-422X-6-5. View

Wang W, Zhang W, Zhang J, He J, Zhu F . Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease-2019 (COVID-19). HLA. 2020; 96(2):194-196. PMC: 7276866. DOI: 10.1111/tan.13941. View

Bradley B, Maioli H, Johnston R, Chaudhry I, Fink S, Xu H . Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. Lancet. 2020; 396(10247):320-332. PMC: 7365650. DOI: 10.1016/S0140-6736(20)31305-2. View

Pastor S, Molina Sr A, de Celis E . Thyrotoxic Crisis and COVID-19 Infection: An Extraordinary Case and Literature Review. Cureus. 2020; 12(11):e11305. PMC: 7714732. DOI: 10.7759/cureus.11305. View

10.

Dixit N, Truong K, Rabadia S, Li D, Srivastava P, Mosaferi T . Sudden Cardiac Arrest in a Patient With Myxedema Coma and COVID-19. J Endocr Soc. 2020; 4(10):bvaa130. PMC: 7499619. DOI: 10.1210/jendso/bvaa130. View

11.

De Carli M, DElios M, Zancuoghi G, Romagnani S, Del Prete G . Human Th1 and Th2 cells: functional properties, regulation of development and role in autoimmunity. Autoimmunity. 1994; 18(4):301-8. DOI: 10.3109/08916939409009532. View

12.

Ito M, Tanimoto M, Kamura H, Yoneda M, Morishima Y, Yamauchi K . Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease and Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1989; 69(1):100-4. DOI: 10.1210/jcem-69-1-100. View

13.

Gonzalez-Aguilera B, Betea D, Lutteri L, Cavalier E, Geenen V, Beckers A . Conversion to Graves disease from Hashimoto thyroiditis: a study of 24 patients. Arch Endocrinol Metab. 2019; 62(6):609-614. PMC: 10118676. DOI: 10.20945/2359-3997000000086. View

14.

Tan T, Khoo B, Mills E, Phylactou M, Patel B, Eng P . Association between high serum total cortisol concentrations and mortality from COVID-19. Lancet Diabetes Endocrinol. 2020; 8(8):659-660. PMC: 7302794. DOI: 10.1016/S2213-8587(20)30216-3. View

15.

Harris A, Al Mushref M . Graves' Thyrotoxicosis Following SARS-CoV-2 Infection. AACE Clin Case Rep. 2021; 7(1):14-16. PMC: 7834282. DOI: 10.1016/j.aace.2020.12.005. View

16.

Halpert G, Shoenfeld Y . SARS-CoV-2, the autoimmune virus. Autoimmun Rev. 2020; 19(12):102695. PMC: 7598743. DOI: 10.1016/j.autrev.2020.102695. View

17.

Novelli A, Andreani M, Biancolella M, Liberatoscioli L, Passarelli C, Colona V . HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients. HLA. 2020; 96(5):610-614. PMC: 7461491. DOI: 10.1111/tan.14047. View

18.

Yao X, Li T, He Z, Ping Y, Liu H, Yu S . [A pathological report of three COVID-19 cases by minimal invasive autopsies]. Zhonghua Bing Li Xue Za Zhi. 2020; 49(5):411-417. DOI: 10.3760/cma.j.cn112151-20200312-00193. View

19.

Ohsako N, Tamai H, Sudo T, Mukuta T, Tanaka H, Kuma K . Clinical characteristics of subacute thyroiditis classified according to human leukocyte antigen typing. J Clin Endocrinol Metab. 1995; 80(12):3653-6. DOI: 10.1210/jcem.80.12.8530615. View

20.

Tanaka T, Narazaki M, Kishimoto T . IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014; 6(10):a016295. PMC: 4176007. DOI: 10.1101/cshperspect.a016295. View