Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure

Overview

Journal Front Physiol

Date 2021 Jul 19

PMID 34276413

Citations 17

Authors

Huihui Li

Chen Chen

Dao Wen Wang

Affiliations

Soon will be listed here.

Abstract

Despite mounting evidence demonstrating the significance of inflammation in the pathophysiological mechanisms of heart failure (HF), most large clinical trials that target the inflammatory responses in HF yielded neutral or even worsening outcomes. Further in-depth understanding about the roles of inflammation in the pathogenesis of HF is eagerly needed. This review summarizes cytokines, cardiac infiltrating immune cells, and extracardiac organs that orchestrate the complex inflammatory responses in HF and highlights emerging therapeutic targets.

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References

Hou N, Zhao D, Liu Y, Gao L, Liang X, Liu X . Increased expression of T cell immunoglobulin- and mucin domain-containing molecule-3 on natural killer cells in atherogenesis. Atherosclerosis. 2012; 222(1):67-73. DOI: 10.1016/j.atherosclerosis.2012.02.009. View

Laroumanie F, Douin-Echinard V, Pozzo J, Lairez O, Tortosa F, Vinel C . CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload. Circulation. 2014; 129(21):2111-24. DOI: 10.1161/CIRCULATIONAHA.113.007101. View

Sandanger O, Ranheim T, Vinge L, Bliksoen M, Alfsnes K, Finsen A . The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2013; 99(1):164-74. DOI: 10.1093/cvr/cvt091. View

Eriksson U, Ricci R, Hunziker L, Kurrer M, Oudit G, Watts T . Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med. 2003; 9(12):1484-90. DOI: 10.1038/nm960. View

Weinberg E, Shimpo M, Hurwitz S, Tominaga S, Rouleau J, Lee R . Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation. 2003; 107(5):721-6. DOI: 10.1161/01.cir.0000047274.66749.fe. View

Kalra D, Sivasubramanian N, Mann D . Angiotensin II induces tumor necrosis factor biosynthesis in the adult mammalian heart through a protein kinase C-dependent pathway. Circulation. 2002; 105(18):2198-205. DOI: 10.1161/01.cir.0000015603.84788.47. View

Anderson J, Carlquist J, Hammond E . Deficient natural killer cell activity in patients with idiopathic dilated cardiomyopathy. Lancet. 1982; 2(8308):1124-7. DOI: 10.1016/s0140-6736(82)92786-6. View

Wollenweber T, Roentgen P, Schafer A, Schatka I, Zwadlo C, Brunkhorst T . Characterizing the inflammatory tissue response to acute myocardial infarction by clinical multimodality noninvasive imaging. Circ Cardiovasc Imaging. 2014; 7(5):811-8. DOI: 10.1161/CIRCIMAGING.114.001689. View

Tromp J, Tay W, Ouwerkerk W, Teng T, Yap J, MacDonald M . Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. PLoS Med. 2018; 15(3):e1002541. PMC: 5870945. DOI: 10.1371/journal.pmed.1002541. View

10.

Berg A, Scherer P . Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005; 96(9):939-49. DOI: 10.1161/01.RES.0000163635.62927.34. View

11.

Kim M, Tomita T, Kim M, Sasai H, Maeda S, Tanaka K . Aerobic exercise training reduces epicardial fat in obese men. J Appl Physiol (1985). 2008; 106(1):5-11. DOI: 10.1152/japplphysiol.90756.2008. View

12.

Kang S, Tanaka T, Narazaki M, Kishimoto T . Targeting Interleukin-6 Signaling in Clinic. Immunity. 2019; 50(4):1007-1023. DOI: 10.1016/j.immuni.2019.03.026. View

13.

Hulsmans M, Clauss S, Xiao L, Aguirre A, King K, Hanley A . Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017; 169(3):510-522.e20. PMC: 5474950. DOI: 10.1016/j.cell.2017.03.050. View

14.

Berezin A, Berezin A, Lichtenauer M . Myokines and Heart Failure: Challenging Role in Adverse Cardiac Remodeling, Myopathy, and Clinical Outcomes. Dis Markers. 2021; 2021:6644631. PMC: 7819753. DOI: 10.1155/2021/6644631. View

15.

Sharma K, Patel A, Shah K, Konat A . Is Neutrophil-to-Lymphocyte Ratio a Predictor of Coronary Artery Disease in Western Indians?. Int J Inflam. 2017; 2017:4136126. PMC: 5546050. DOI: 10.1155/2017/4136126. View

16.

Kapadia S, Lee J, Torre-Amione G, Birdsall H, Ma T, Mann D . Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration. J Clin Invest. 1995; 96(2):1042-52. PMC: 286384. DOI: 10.1172/JCI118090. View

17.

Martini E, Kunderfranco P, Peano C, Carullo P, Cremonesi M, Schorn T . Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation. Circulation. 2019; 140(25):2089-2107. DOI: 10.1161/CIRCULATIONAHA.119.041694. View

18.

Van Tassell B, Seropian I, Toldo S, Mezzaroma E, Abbate A . Interleukin-1β induces a reversible cardiomyopathy in the mouse. Inflamm Res. 2013; 62(7):637-40. DOI: 10.1007/s00011-013-0625-0. View

19.

Kaya Z, Leib C, Katus H . Autoantibodies in heart failure and cardiac dysfunction. Circ Res. 2012; 110(1):145-58. DOI: 10.1161/CIRCRESAHA.111.243360. View

20.

Liu L, Wang Y, Cao Z, Wang M, Liu X, Gao T . Up-regulated TLR4 in cardiomyocytes exacerbates heart failure after long-term myocardial infarction. J Cell Mol Med. 2015; 19(12):2728-40. PMC: 4687701. DOI: 10.1111/jcmm.12659. View