Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Overview

Journal Front Pharmacol

Date 2021 Jul 19

PMID 34276374

Citations 27

Authors

Qiang Sun

Man He

Meng Zhang

Sha Zeng

Li Chen

Hui Zhao

Han Yang

Maolun Liu

Shan Ren

Haibo Xu

Affiliations

Soon will be listed here.

Abstract

As an important part of complementary and alternative medicine, traditional Chinese medicine (TCM) has been applied to treat a host of diseases for centuries. Over the years, with the incidence rate of human colorectal cancer (CRC) increasing continuously and the advantage of TCM gradually becoming more prominent, the importance of TCM in both domestic and international fields is also growing with each passing day. However, the unknowability of active ingredients, effective substances, and the underlying mechanisms of TCM against this malignant tumor greatly restricts the translation degree of clinical products and the pace of precision medicine. In this review, based on the characteristics of TCM and the oral administration of most ingredients, we herein provide beneficial information for the clinical utilization of TCM in the prevention and treatment of CRC and retrospect the current preclinical studies on the related active ingredients, as well as put forward the research mode for the discovery of active ingredients and effective substances in TCM, to provide novel insights into the research and development of innovative agents from this conventional medicine for CRC treatment and assist the realization of precision medicine.

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References

Su T, Bai J, Chen Y, Wang X, Fu X, Li T . An Ethanolic Extract of Ampelopsis Radix Exerts Anti-colorectal Cancer Effects and Potently Inhibits STAT3 Signaling . Front Pharmacol. 2017; 8:227. PMC: 5408070. DOI: 10.3389/fphar.2017.00227. View

Wong S, Chin K, Ima-Nirwana S . Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence. Int J Mol Sci. 2020; 21(17). PMC: 7503351. DOI: 10.3390/ijms21176448. View

Andujar I, Marti-Rodrigo A, Giner R, Rios J, Recio M . Shikonin Prevents Early Phase Inflammation Associated with Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer and Induces Apoptosis in Human Colon Cancer Cells. Planta Med. 2018; 84(9-10):674-683. DOI: 10.1055/a-0599-1145. View

Liang W, Cui J, Zhang K, Xi H, Cai A, Li J . Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer. Oncotarget. 2018; 8(65):109094-109106. PMC: 5752506. DOI: 10.18632/oncotarget.22618. View

Qiu J . China plans to modernize traditional medicine. Nature. 2007; 446(7136):590-1. DOI: 10.1038/446590a. View

Zhang L, Fang Y, Feng J, Cai Q, Wei L, Lin S . Chloroform fraction of Scutellaria barbata D. Don inhibits the growth of colorectal cancer cells by activating miR‑34a. Oncol Rep. 2017; 37(6):3695-3701. DOI: 10.3892/or.2017.5625. View

Zhang L, Naeem A, Wei S, Li Z, Zang Z, Wang M . PPTS Inhibits the TGF-1-Induced Epithelial-Mesenchymal Transition in Human Colorectal Cancer SW480 Cells. Evid Based Complement Alternat Med. 2019; 2019:2683534. PMC: 6778905. DOI: 10.1155/2019/2683534. View

Qi J, Yu J, Li Y, Luo J, Zhang C, Ou S . Alternating consumption of β-glucan and quercetin reduces mortality in mice with colorectal cancer. Food Sci Nutr. 2019; 7(10):3273-3285. PMC: 6804767. DOI: 10.1002/fsn3.1187. View

Shen Z, Wang J, Tan W, Huang T . Berberine inhibits colorectal tumor growth by suppressing SHH secretion. Acta Pharmacol Sin. 2020; 42(7):1190-1194. PMC: 8209003. DOI: 10.1038/s41401-020-00514-2. View

10.

Juan T, Liu K, Kuo C, Yang M, Chu Y, Yang J . Tetrandrine suppresses adhesion, migration and invasion of human colon cancer SW620 cells via inhibition of nuclear factor-κB, matrix metalloproteinase-2 and matrix metalloproteinase-9 signaling pathways. Oncol Lett. 2018; 15(5):7716-7724. PMC: 5921181. DOI: 10.3892/ol.2018.8286. View

11.

Zhang S, Yang Y, Hua Y, Hu C, Zhong Y . NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling. Mol Med Rep. 2020; 22(2):774-782. PMC: 7339822. DOI: 10.3892/mmr.2020.11151. View

12.

Li S, Wang X, Wang G, Shi P, Lin S, Xu D . Ethyl Acetate Extract of Hieron Induces Cell Autophagic Death and Apoptosis in Colorectal Cancer PI3K-Akt-mTOR and AMPKα-Signaling Pathways. Front Pharmacol. 2020; 11:565090. PMC: 7604386. DOI: 10.3389/fphar.2020.565090. View

13.

Xiang L, He B, Liu Q, Hu D, Liao W, Li R . Antitumor effects of curcumin on the proliferation, migration and apoptosis of human colorectal carcinoma HCT‑116 cells. Oncol Rep. 2020; 44(5):1997-2008. PMC: 7550984. DOI: 10.3892/or.2020.7765. View

14.

Sui H, Duan P, Guo P, Hao L, Liu X, Zhang J . Zhi Zhen Fang formula reverses Hedgehog pathway mediated multidrug resistance in colorectal cancer. Oncol Rep. 2017; 38(4):2087-2095. PMC: 5652964. DOI: 10.3892/or.2017.5917. View

15.

Almeida A, Borge G, Piskula M, Tudose A, Tudoreanu L, Valentova K . Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation. Compr Rev Food Sci Food Saf. 2020; 17(3):714-731. DOI: 10.1111/1541-4337.12342. View

16.

Chamseddine A, Ducreux M, Armand J, Paoletti X, Satar T, Paci A . Intestinal bacterial β-glucuronidase as a possible predictive biomarker of irinotecan-induced diarrhea severity. Pharmacol Ther. 2019; 199:1-15. DOI: 10.1016/j.pharmthera.2019.03.002. View

17.

Leigh A, Cheung H, Lin L, Ng T, Lao L, Zhang Y . Comprehensive and Holistic Analysis of HT-29 Colorectal Cancer Cells and Tumor-Bearing Nude Mouse Model: Interactions Among Fractions Derived From the Chinese Medicine Formula Tian Xian Liquid in Effects on Human Colorectal Carcinoma. Integr Cancer Ther. 2016; 16(3):339-350. PMC: 5759938. DOI: 10.1177/1534735416651969. View

18.

Yao Y, Rao C, Zheng G, Wang S . Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis. Oncol Rep. 2019; 42(1):131-141. PMC: 6549074. DOI: 10.3892/or.2019.7136. View

19.

Yang N, Zhao Y, Wang Z, Liu Y, Zhang Y . Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Mol Med Rep. 2016; 15(2):929-935. DOI: 10.3892/mmr.2016.6081. View

20.

Han W, Yin H, Ma H, Wang Y, Kong D, Fan Z . Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p. Evid Based Complement Alternat Med. 2020; 2020:8394574. PMC: 7519441. DOI: 10.1155/2020/8394574. View