B3Pdb: an Archive of Blood-brain Barrier-penetrating Peptides

Overview

Journal Brain Struct Funct

Specialty Neurology

Date 2021 Jul 16

PMID 34269889

Citations 12

Authors

Vinod Kumar

Sumeet Patiyal

Rajesh Kumar

Sukriti Sahai

Dilraj Kaur

Anjali Lathwal

Gajendra P S Raghava

Affiliations

Soon will be listed here.

Abstract

The blood-brain barrier poses major hurdles in the treatment of brain-related ailments. Over the past decade, interest in peptides-based therapeutics has thrived a lot because of their higher benefit to risk ratio. However, a complete knowledgebase providing a well-annotated picture of the peptide as a therapeutic molecule to cure brain-related ailments is lacking. We have built up a knowledgebase B3Pdb on blood-brain barrier (BBB)-penetrating peptides in the present study. The B3Pdb holds clinically relevant experimental information on 1225 BBB-penetrating peptides, including mode of delivery, animal model, in vitro/in vivo experiments, chemical modifications, length. Hoping that drug delivery systems can improve central nervous system disorder-related therapeutics. In this regard, B3Pdb is an important resource to support the rational design of therapeutics peptides for CNS-related disorders. The complete ready-to-use and updated database with a user-friendly web interface is available to the scientific community at https://webs.iiitd.edu.in/raghava/b3pdb/ .

Citing Articles

Computational Modeling of Pharmaceuticals with an Emphasis on Crossing the Blood-Brain Barrier.

Alves P, Camargo L, Souza G, Mortari M, Homem-de-Mello M Pharmaceuticals (Basel). 2025; 18(2).

PMID: 40006031 PMC: 11860133. DOI: 10.3390/ph18020217.

Prediction of blood-brain barrier penetrating peptides based on data augmentation with Augur.

Gu Z, Hao Y, Wang T, Cai P, Zhang Y, Deng K BMC Biol. 2024; 22(1):86.

PMID: 38637801 PMC: 11027412. DOI: 10.1186/s12915-024-01883-4.

BBB-PEP-prediction: improved computational model for identification of blood-brain barrier peptides using blending position relative composition specific features and ensemble modeling.

Naseem A, Alturise F, Alkhalifah T, Khan Y J Cheminform. 2023; 15(1):110.

PMID: 37980534 PMC: 10656963. DOI: 10.1186/s13321-023-00773-1.

Peptides for trans-blood-brain barrier delivery.

Blades R, Ittner L, Tietz O J Labelled Comp Radiopharm. 2023; 66(9):237-248.

PMID: 37002811 PMC: 10952576. DOI: 10.1002/jlcr.4023.

Development of an apolipoprotein E mimetic peptide-lipid conjugate for efficient brain delivery of liposomes.

Kato N, Yamada S, Suzuki R, Iida Y, Matsumoto M, Fumoto S Drug Deliv. 2023; 30(1):2173333.

PMID: 36718920 PMC: 9891163. DOI: 10.1080/10717544.2023.2173333.

References

Almeida C, Serra T, Oliveira M, Planell J, Barbosa M, Navarro M . Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: unraveling the effect of 3-D structures on inflammation. Acta Biomater. 2013; 10(2):613-22. DOI: 10.1016/j.actbio.2013.10.035. View

Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood M . Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011; 29(4):341-5. DOI: 10.1038/nbt.1807. View

Bertrand Y, Currie J, Poirier J, Demeule M, Abulrob A, Fatehi D . Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1. Br J Cancer. 2011; 105(11):1697-707. PMC: 3242593. DOI: 10.1038/bjc.2011.427. View

Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Muller U . Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development. 2004; 131(9):2173-81. DOI: 10.1242/dev.01103. View

Che C, Yang G, Thiot C, Lacoste M, Currie J, Demeule M . New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J Med Chem. 2010; 53(7):2814-24. DOI: 10.1021/jm9016637. View

Demeule M, Currie J, Bertrand Y, Che C, Nguyen T, Regina A . Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J Neurochem. 2008; 106(4):1534-44. DOI: 10.1111/j.1471-4159.2008.05492.x. View

Demeule M, Regina A, Che C, Poirier J, Nguyen T, Gabathuler R . Identification and design of peptides as a new drug delivery system for the brain. J Pharmacol Exp Ther. 2007; 324(3):1064-72. DOI: 10.1124/jpet.107.131318. View

Drin G, Cottin S, Blanc E, Rees A, Temsamani J . Studies on the internalization mechanism of cationic cell-penetrating peptides. J Biol Chem. 2003; 278(33):31192-201. DOI: 10.1074/jbc.M303938200. View

Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E . Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011; 21(10):718-79. DOI: 10.1016/j.euroneuro.2011.08.008. View

10.

Hwang D, Son S, Jang J, Youn H, Lee S, Lee D . A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA. Biomaterials. 2011; 32(21):4968-75. DOI: 10.1016/j.biomaterials.2011.03.047. View

11.

Ke W, Shao K, Huang R, Han L, Liu Y, Li J . Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials. 2009; 30(36):6976-85. DOI: 10.1016/j.biomaterials.2009.08.049. View

12.

Kumar P, Wu H, McBride J, Jung K, Kim M, Davidson B . Transvascular delivery of small interfering RNA to the central nervous system. Nature. 2007; 448(7149):39-43. DOI: 10.1038/nature05901. View

13.

Kurzrock R, Gabrail N, Chandhasin C, Moulder S, Smith C, Brenner A . Safety, pharmacokinetics, and activity of GRN1005, a novel conjugate of angiopep-2, a peptide facilitating brain penetration, and paclitaxel, in patients with advanced solid tumors. Mol Cancer Ther. 2011; 11(2):308-16. DOI: 10.1158/1535-7163.MCT-11-0566. View

14.

Lathwal A, Kumar R, Raghava G . OvirusTdb: A database of oncolytic viruses for the advancement of therapeutics in cancer. Virology. 2020; 548:109-116. DOI: 10.1016/j.virol.2020.05.016. View

15.

Lo S, Wang S . An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection. Biomaterials. 2008; 29(15):2408-14. DOI: 10.1016/j.biomaterials.2008.01.031. View

16.

Prades R, Guerrero S, Araya E, Molina C, Salas E, Zurita E . Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor. Biomaterials. 2012; 33(29):7194-205. DOI: 10.1016/j.biomaterials.2012.06.063. View

17.

Ren J, Shen S, Wang D, Xi Z, Guo L, Pang Z . The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. Biomaterials. 2012; 33(11):3324-33. DOI: 10.1016/j.biomaterials.2012.01.025. View

18.

Ronaldson P, Persidsky Y, Bendayan R . Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia. 2008; 56(16):1711-35. DOI: 10.1002/glia.20725. View

19.

Schwarze S, Ho A, Dowdy S . In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 1999; 285(5433):1569-72. DOI: 10.1126/science.285.5433.1569. View

20.

Vizioli N, Rusell M, Carbajal M, Carducci C, Grasselli M . On-line affinity selection of histidine-containing peptides using a polymeric monolithic support for capillary electrophoresis. Electrophoresis. 2005; 26(15):2942-8. DOI: 10.1002/elps.200410416. View