Early Oral Contraceptive Use and Breast Cancer: Results of Another Case-control Study

Overview

Journal Br J Cancer

Specialty Oncology

Date 1987 Nov 1

PMID 3426932

Citations 32

Authors

K McPherson

M P Vessey

A Neil

R DOLL

L Jones

M Roberts

Affiliations

Soon will be listed here.

Abstract

We report the results of a case-control study of oral contraceptive use and breast cancer conducted in London, Oxford and Edinburgh between 1980 and 1984. One thousand one hundred and twenty-five women aged 16-64 years with newly diagnosed breast cancer and a like number of matched controls were interviewed and asked about their past due use of oral contraceptives (OCs). Among women aged 45 years or more at diagnosis there was no evidence of an association between OC use and breast cancer. Among the 351 pairs of women aged under 45 years at diagnosis there was a significantly elevated risk associated with increasing duration of use before first full term pregnancy (relative risk for 4+ years use versus never use = 2.6, 95% confidence limits, 1.3-5.4). Since this result is at variance with the findings in some other studies we have investigated the nature of this association with particular emphasis on possible bias, pill type and a latent effect.

Citing Articles

Use of Oral Contraceptives as a Potential Risk Factor for Breast Cancer: A Systematic Review and Meta-Analysis of Case-Control Studies Up to 2010.

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Previous oral contraceptive use and breast cancer risk according to hormone replacement therapy use among postmenopausal women.

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Hormonal content and potency of oral contraceptives and breast cancer risk among young women.

Althuis M, Brogan D, Coates R, Daling J, Gammon M, Malone K Br J Cancer. 2003; 88(1):50-7.

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Breast cancer hypothesis: a single cause for the majority of cases.

Wiseman R J Epidemiol Community Health. 2000; 54(11):851-8.

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Oral contraceptive use at a young age and the risk of breast cancer: an Icelandic, population-based cohort study of the effect of birth year.

Tryggvadottir L, Tulinius H, Gudmundsdottir G Br J Cancer. 1997; 75(1):139-43.

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References

MacMahon B, Cole P, Brown J . Etiology of human breast cancer: a review. J Natl Cancer Inst. 1973; 50(1):21-42. DOI: 10.1093/jnci/50.1.21. View

McPherson K, Coope P, Vessey M . Early oral contraceptive use and breast cancer: theoretical effects of latency. J Epidemiol Community Health. 1986; 40(4):289-94. PMC: 1052548. DOI: 10.1136/jech.40.4.289. View

Paffenbarger Jr R, Fasal E, Simmons M, Kampert J . Cancer risk as related to use of oral contraceptives during fertile years. Cancer. 1977; 39(4 Suppl):1887-91. DOI: 10.1002/1097-0142(197704)39:4+<1887::aid-cncr2820390822>3.0.co;2-i. View

Tokunaga M, Norman Jr J, Asano M, Tokuoka S, Ezaki H, Nishimori I . Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. J Natl Cancer Inst. 1979; 62(6):1347-59. View

Korenman S . Oestrogen window hypothesis of the aetiology of breast cancer. Lancet. 1980; 1(8170):700-1. View

Pike M, Henderson B, Casagrande J, Rosario I, Gray G . Oral contraceptive use and early abortion as risk factors for breast cancer in young women. Br J Cancer. 1981; 43(1):72-6. PMC: 2010485. DOI: 10.1038/bjc.1981.10. View

Drife J . Breast cancer, pregnancy, and the pill. Br Med J (Clin Res Ed). 1981; 283(6294):778-9. PMC: 1506817. DOI: 10.1136/bmj.283.6294.778. View

Vessey M, McPherson K, Yeates D, DOLL R . Oral contraceptive use and abortion before first term pregnancy in relation to breast cancer risk. Br J Cancer. 1982; 45(3):327-31. PMC: 2010930. DOI: 10.1038/bjc.1982.58. View

Harris N, Weiss N, Francis A, Polissar L . Breast cancer in relation to patterns of oral contraceptive use. Am J Epidemiol. 1982; 116(4):643-51. DOI: 10.1093/oxfordjournals.aje.a113447. View

10.

Vessey M, Baron J, DOLL R, McPherson K, Yeates D . Oral contraceptives and breast cancer: final report of an epidemiological study. Br J Cancer. 1983; 47(4):455-62. PMC: 2011321. DOI: 10.1038/bjc.1983.74. View

11.

Orme M, Back D, Breckenridge A . Clinical pharmacokinetics of oral contraceptive steroids. Clin Pharmacokinet. 1983; 8(2):95-136. DOI: 10.2165/00003088-198308020-00001. View

12.

Pike M, Henderson B, Krailo M, Duke A, Roy S . Breast cancer in young women and use of oral contraceptives: possible modifying effect of formulation and age at use. Lancet. 1983; 2(8356):926-30. DOI: 10.1016/s0140-6736(83)90450-6. View

13.

Armenian H, LILIENFELD A . Incubation period of disease. Epidemiol Rev. 1983; 5:1-15. DOI: 10.1093/oxfordjournals.epirev.a036254. View

14.

McPherson K, Neil A, Vessey M, DOLL R . Oral contraceptives and breast cancer. Lancet. 1983; 2(8364):1414-5. DOI: 10.1016/s0140-6736(83)90936-4. View

15.

Rosenberg L, Miller D, Kaufman D, Helmrich S, STOLLEY P, Schottenfeld D . Breast cancer and oral contraceptive use. Am J Epidemiol. 1984; 119(2):167-76. DOI: 10.1093/oxfordjournals.aje.a113735. View

16.

Greenberg E, Barnes A, RESSEGUIE L, Barrett J, Burnside S, Lanza L . Breast cancer in mothers given diethylstilbestrol in pregnancy. N Engl J Med. 1984; 311(22):1393-8. DOI: 10.1056/NEJM198411293112201. View

17.

Olsson H, Olsson M, Moller T, Ranstam J, Holm P . Oral contraceptive use and breast cancer in young women in Sweden. Lancet. 1985; 1(8431):748-9. DOI: 10.1016/s0140-6736(85)91280-2. View

18.

Stadel B, Rubin G, Webster L, Schlesselman J, Wingo P . Oral contraceptives and breast cancer in young women. Lancet. 1985; 2(8462):970-3. DOI: 10.1016/s0140-6736(85)90524-0. View

19.

Coulter A, Vessey M, McPherson K, Crossley B . The ability of women to recall their oral contraceptive histories. Contraception. 1986; 33(2):127-37. DOI: 10.1016/0010-7824(86)90079-x. View

20.

Meirik O, Lund E, Adami H, Bergstrom R, Christoffersen T, Bergsjo P . Oral contraceptive use and breast cancer in young women. A joint national case-control study in Sweden and Norway. Lancet. 1986; 2(8508):650-4. DOI: 10.1016/s0140-6736(86)90166-2. View