The MicroRNA MiR-21 Conditions the Brain to Protect Against Ischemic and Traumatic Injuries

Overview

Journal Cond Med

Date 2021 Jul 16

PMID 34268484

Citations 5

Authors

Mary S Lopez

Robert J Dempsey

Raghu Vemuganti

Affiliations

Soon will be listed here.

Abstract

Ischemic and traumatic injuries to CNS remain leading causes of death and disability worldwide, despite decades of research into risk factors, therapies, and preventative measures. Recent studies showed that CNS injuries significantly alter the cerebral microRNAome that impact the secondary brain damage as well as plasticity and recovery. Many microRNA based therapies are currently in various clinical trials for different pathologic conditions indicating their therapeutic potential. In the present review, we discuss the role of miR-21 in acute CNS injuries which is currently thought to be a potent neuroprotective microRNA. We emphasize on the potential of miR-21 in promoting cell and tissue survival and preventing inflammation and apoptosis. We also discussed the role of miR-21 in conditioning the brain to promote ischemic tolerance. Finally, we discussed some of the challenges and difficulties to develop miR-21 as a neuroprotective therapy in humans.

Citing Articles

The Therapeutic Potential of MicroRNA-21 in the Treatment of Spinal Cord Injury.

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Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention.

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Deciphering the Role of microRNAs: Unveiling Clinical Biomarkers and Therapeutic Avenues in Atrial Fibrillation and Associated Stroke-A Systematic Review.

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Therapeutic Potential of Intravenous miR-21 Mimic after Stroke Following STAIR Criteria.

Chelluboina B, Jeong S, Davis C, Mehta S, Vemuganti R Transl Stroke Res. 2023; .

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Commentary: Can astrocytic mitochondria therapy be used as antioxidant conditioning to protect neurons?.

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PMID: 38037662 PMC: 10688760.

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