Mitoprotective Effects of (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

Overview

Journal Front Pharmacol

Date 2021 Jul 16

PMID 34267660

Citations 11

Authors

Jia Hui Wong

Anna M Barron

Jafri Malin Abdullah

Affiliations

Soon will be listed here.

Abstract

Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past and studies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer's disease and Parkinson's disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

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