No Association Between Alcohol Consumption and Pancreatic Cancer Even Among Individuals Genetically Susceptible to the Carcinogenicity of Alcohol

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jul 16

PMID 34267279

Citations 6

Authors

Yan-Shen Shan

Li-Tzong Chen

Chih-Hsing Wu

Yin-Fan Chang

Chih-Ting Lee

Nai-Jung Chiang

Ying-Jui Chao

Chia-Jui Yen

Hui-Jen Tsai

Hsin-En Huang

Chia-Rung Tsai

Ya-Ling Weng

Han-Chien Yang

Hui-Chin Liu

Jeffrey S Chang

Affiliations

Soon will be listed here.

Abstract

Inconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol. The current study investigated the association between alcohol use and pancreatic cancer with 419 pancreatic cancer cases and 963 controls recruited by a hospital-based case-control study in Taiwan. Gene-environment interaction between alcohol use and polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on pancreatic risk was evaluated. Our results showed no significant association between alcohol drinking and an increased pancreatic cancer risk, even at high levels of alcohol consumption. Even among those genetically susceptible to the carcinogenic effect of alcohol (carriers of ADH1B*2/*2(fast activity) combined with ALDH2*1/*2(slow activity) or ALDH2*2/*2(almost non-functional)), no significant association between alcohol use and pancreatic cancer was observed. Overall, our results suggested that alcohol drinking is not a significant contributor to the occurrence of pancreatic cancer in Taiwan.

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