Redefining Actin Dynamics of the Pointed-end Complex in Striated Muscle

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2021 Jul 16

PMID 34266732

Citations 4

Authors

Jessika Iwanski

Carol C Gregorio

Mert Colpan

Affiliations

Soon will be listed here.

Abstract

Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.

Citing Articles

Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction.

Iwanski J, Pappas C, Mayfield R, Farman G, Ahrens-Nicklas R, Churko J NPJ Regen Med. 2024; 9(1):21.

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Lmod2 is necessary for effective skeletal muscle contraction.

Larrinaga T, Farman G, Mayfield R, Yuen M, Ahrens-Nicklas R, Cooper S Sci Adv. 2024; 10(11):eadk1890.

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Actin polymerization and depolymerization in developing vertebrates.

Bai Y, Zhao F, Wu T, Chen F, Pang X Front Physiol. 2023; 14:1213668.

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Recycling of the actin monomer pool limits the lifetime of network turnover.

Colin A, Kotila T, Guerin C, Orhant-Prioux M, Vianay B, Mogilner A EMBO J. 2023; 42(9):e112717.

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References

Ahrens-Nicklas R, Pappas C, Farman G, Mayfield R, Larrinaga T, Medne L . Disruption of cardiac thin filament assembly arising from a mutation in : A novel mechanism of neonatal dilated cardiomyopathy. Sci Adv. 2019; 5(9):eaax2066. PMC: 6726455. DOI: 10.1126/sciadv.aax2066. View

Peche V, Holak T, Burgute B, Kosmas K, Kale S, Wunderlich F . Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy. Cell Mol Life Sci. 2012; 70(3):527-43. PMC: 11113306. DOI: 10.1007/s00018-012-1142-y. View

Bertling E, Hotulainen P, Mattila P, Matilainen T, Salminen M, Lappalainen P . Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol Biol Cell. 2004; 15(5):2324-34. PMC: 404026. DOI: 10.1091/mbc.e04-01-0048. View

Purde V, Busch F, Kudryashova E, Wysocki V, Kudryashov D . Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins. Int J Mol Sci. 2019; 20(22). PMC: 6888645. DOI: 10.3390/ijms20225647. View

Pappas C, Mayfield R, Henderson C, Jamilpour N, Cover C, Hernandez Z . Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proc Natl Acad Sci U S A. 2015; 112(44):13573-8. PMC: 4640780. DOI: 10.1073/pnas.1508273112. View

Aspit L, Levitas A, Etzion S, Krymko H, Slanovic L, Zarivach R . CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy. J Med Genet. 2018; 56(4):228-235. DOI: 10.1136/jmedgenet-2018-105498. View

Fowler V, Dominguez R . Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles. Biophys J. 2017; 112(9):1742-1760. PMC: 5425412. DOI: 10.1016/j.bpj.2017.03.034. View

Kotila T, Wioland H, Enkavi G, Kogan K, Vattulainen I, Jegou A . Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin. Nat Commun. 2019; 10(1):5320. PMC: 6876575. DOI: 10.1038/s41467-019-13213-2. View

Kepser L, Damar F, De Cicco T, Chaponnier C, Proszynski T, Pagenstecher A . CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function. Proc Natl Acad Sci U S A. 2019; 116(17):8397-8402. PMC: 6486752. DOI: 10.1073/pnas.1813351116. View

10.

Yuen M, Sandaradura S, Dowling J, Kostyukova A, Moroz N, Quinlan K . Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy. J Clin Invest. 2014; 124(11):4693-708. PMC: 4347224. DOI: 10.1172/JCI75199. View

11.

Tolkatchev D, Smith Jr G, Schultz L, Colpan M, Helms G, Cort J . Leiomodin creates a leaky cap at the pointed end of actin-thin filaments. PLoS Biol. 2020; 18(9):e3000848. PMC: 7500696. DOI: 10.1371/journal.pbio.3000848. View

12.

Colpan M, Iwanski J, Gregorio C . CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle. Commun Biol. 2021; 4(1):365. PMC: 7979805. DOI: 10.1038/s42003-021-01893-w. View

13.

Rust M, Khudayberdiev S, Pelucchi S, Marcello E . CAPt'n of Actin Dynamics: Recent Advances in the Molecular, Developmental and Physiological Functions of Cyclase-Associated Protein (CAP). Front Cell Dev Biol. 2020; 8:586631. PMC: 7543520. DOI: 10.3389/fcell.2020.586631. View

14.

Xiong Y, Bedi K, Berritt S, Attipoe B, Brooks T, Wang K . Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. JCI Insight. 2019; 4(6). PMC: 6483011. DOI: 10.1172/jci.insight.124629. View