Expression of Transcription Factor in Human Tissues

Overview

Journal J Histochem Cytochem

Publisher Sage Publications

Specialty Biochemistry

Date 2021 Jul 15

PMID 34261344

Citations 6

Authors

Heidi Kaprio

Vanina D Heuser

Katri Orte

Mikko Tukiainen

Ilmo Leivo

Maria Gardberg

Affiliations

Soon will be listed here.

Abstract

Cyclic AMP element modulator (CREM) is a transcription factor best known for its intricate involvement in spermatogenesis. The gene encodes for multiple protein isoforms, which can enhance or repress transcription of target genes. Recent studies have identified fusion genes, with as a partner gene in many neoplastic diseases. fusion genes have been found in several mesenchymal tumors and in salivary gland carcinoma. These genes encode fusion proteins that include the C-terminal DNA-binding domain of CREM. We used a transcriptomic approach and immunohistochemistry to study the expression of CREM isoforms that include DNA-binding domains across human tissues. We found that CREM protein is widely expressed in almost all normal human tissues. A transcriptomic analysis of normal tissues and cancer showed that transcription of can be altered in tumors, suggesting that also wild-type CREM may be involved in cancer biology. The wide expression of CREM protein in normal human tissues and cancer may limit the utility of immunohistochemistry for identification of tumors with fusions.

Citing Articles

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[High expression of CREM is associated with poor prognosis in gastric cancer patients].

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Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.

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The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.

Kaprio H, Siddiqui A, Saustila L, Heuser V, Gardberg M Sci Rep. 2023; 13(1):4884.

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