Vitamin D Status and Pulmonary Exacerbations in Children and Adolescents with Cystic Fibrosis: Experience from a Tertiary Care Center

Overview

Journal Lung India

Specialty Pulmonary Medicine

Date 2021 Jul 14

PMID 34259170

Citations 2

Authors

Danish Abdul Aziz

Syeda Khadija Fatima

Haissan Iftikhar

Fatima Mir

Affiliations

Soon will be listed here.

Abstract

Background: The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are not well studied in our part of the world. Therefore, we aimed to ascertain the Vitamin D status in pediatric and adolescent CF patients and its association with pulmonary exacerbations.

Materials And Methods: A retrospective study was conducted at The Aga Khan University Hospital from 2015 to 2018. Patients of CF with sweat chloride value >60 mmol/l and who had at least one measurement of 25 hydroxy Vitamin D (25 OHD) were included in the study. Annual serum Vitamin D levels were documented for enrolled patients and their past 1-year data were analyzed for pulmonary exacerbations, average length of stay, and tracheal/airway colonization with organisms.

Results: 69 patients were included in the study. 28 patients (40.57%) were found to be Vitamin D deficient, 22 patients (31.88%) were Vitamin D insufficient and 19 patients (27.53%) were labeled as Vitamin D insufficient. The average number of exacerbations per year was significantly high in Vitamin D deficient group (3.71 ± 0.96) in comparison with insufficient (3.18 ± 1.09) and sufficient groups (2.26 ± 0.93) (P < 0.001).

Conclusion: Vitamin D deficiency is related to an increased number of annual pulmonary exacerbations and pseudomonas infections.

Citing Articles

Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis.

Farahbakhsh N, Fatahi S, Shirvani A, Motaharifard M, Mohkam M, Tabatabaii S J Health Popul Nutr. 2024; 43(1):11.

PMID: 38233891 PMC: 10795301. DOI: 10.1186/s41043-024-00499-2.

Macronutrient and Micronutrient Intake in Children with Lung Disease.

Knebusch N, Mansour M, Vazquez S, Coss-Bu J Nutrients. 2023; 15(19).

PMID: 37836425 PMC: 10574027. DOI: 10.3390/nu15194142.

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