Lymph Node Fibroblastic Reticular Cells Steer Immune Responses

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2021 Jul 14

PMID 34256989

Citations 32

Authors

Lushen Li

Jing Wu

Reza Abdi

Christopher M Jewell

Jonathan S Bromberg

Affiliations

Soon will be listed here.

Abstract

Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. Recent high-resolution transcriptional and histological analyses have enriched our knowledge of LN FRC genetic and spatial heterogeneities. Here, we summarize updated anatomic, phenotypic, and functional identities of FRC subsets, delve into topological and transcriptional remodeling of FRCs in inflammation, and illustrate the crosstalk between FRCs and immune cells. Discussing FRC functions in immunity and tolerance, we highlight state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases.

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