Antidiabetic Function of MF423-Fermented Rice Bran and Its Effect on Gut Microbiota Structure in Type 2 Diabetic Mice

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2021 Jul 12

PMID 34248898

Citations 20

Authors

Xiaojuan Ai

Cuiling Wu

Tingting Yin

Olena Zhur

Congling Liu

Xiaotao Yan

Cuiping Yi

Dan Liu

Linhu Xiao

Wenkai Li

Binbin Xie

Hailun He

Affiliations

Soon will be listed here.

Abstract

Rice bran is an industrial byproduct that exerts several bioactivities despite its limited bioavailability. In this study, rice bran fermented with MF423 (FLRB) had enhanced antidiabetic effects both and . FLRB could increase glucose consumption and decrease lipid accumulation in insulin resistant HepG2 cells. Eight weeks of FLRB treatment significantly reduced the levels of blood glucose and lipids and elevated antioxidant activity in type 2 diabetic mellitus (T2DM) mice. H&E staining revealed alleviation of overt lesions in the livers of FLRB-treated mice. Moreover, high-throughput sequencing showed notable variation in the composition of gut microbiota in FLRB-treated mice, especially for short-chain fatty acids (SCFAs)-producing bacteria such as and . In conclusion, our results suggested that rice bran fermentation products can modulate the intestinal microbiota and improve T2DM-related biochemical abnormalities, so they can be applied as potential probiotics or dietary supplements.

Citing Articles

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