Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis Via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects

Overview

Journal Front Pharmacol

Date 2021 Jul 12

PMID 34248622

Citations 10

Authors

Dan Huang

Xindong Wang

Yunhong Zhu

Juexiao Gong

Junqing Liang

Yanfei Song

Yiyan Zhang

Linsheng Liu

Cong Wei

Affiliations

Soon will be listed here.

Abstract

(BZBS), as a Chinese medicine used to relieve fatigue, has been proven effective for the treatment of atherogenesis through antilipid effects. To investigate the potential mechanism of BZBS in the anti-atherosclerotic effect, Ovx/ApoE mice were applied to investigate the anti-atherosclerotic efficiency and potential mechanism of BZBS. Therapeutic effect was evaluated based on the number of CD68 and CD3 cells, the level of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), and the ratio of cleaved caspase-3/caspase-3, as well as increasing ratio of Bcl2/Bax. Human umbilical vein endothelial cells (HUVECs) were chosen to evaluate the role of GPER1. Treatment with BZBS reduced lipid deposition by reducing the numbers of CD68 and CD3 cells, the level of ICAM-1 and VCAM-1, and the ratio of cleaved caspase-3/caspase-3, and increasing the ratio of Bcl2/Bax as compared with the control group. In si-GPER1-treated HUVECs, the anti-apoptotic effect of BZBS was decreased. This study revealed that BZBS exhibited a clear effect against atherogenesis GPER1-dependent anti-inflammatory and anti-apoptotic mechanisms. We believe that this manuscript is informative and useful for researchers pursuing the related alleviation of post-menopausal AS anti-inflammatory and anti-apoptotic mechanisms.

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