Growth and Development of Children Under 5 years of Age with Tetralogy of Fallot in a Chinese Population

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jul 10

PMID 34244570

Citations 4

Authors

Xin Li

Jin Zhu

Jun An

Yuqing Wang

Yili Wu

Xuezhi Li

Affiliations

Soon will be listed here.

Abstract

Congenital Heart Defects (CHDs) are associated with different patterns of malnutrition and growth retardation, which may vary worldwide and need to be evaluated according to local conditions. Although tetralogy of Fallot (TOF) is one of the first described CHDs, the etiology outcomes in growth and development of TOF in early age child is still unclear in most cases. This study was designed to investigate the growth retardation status of Chinese pediatric TOF patients under 5 years old. The body height, body weight and body mass index (BMI) of 262 pediatric patients (138 boys and 124 girls) who underwent corrective surgery for TOF between 2014 and 2018 were measured using conventional methods. The average body height, body weight and BMI of the patients were significantly lower than WHO Child Growth Standards, while the most affected was body height. Meanwhile, higher stunting frequency and greater deterioration of both the body height and weight happened in elder age (aged 13-60 months) rather than in infant stage (aged 0-12 months) among these patients. Our results confirmed that intervention should be given at early age to prevent the growth retardation of TOF patients getting severer.

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References

Davis D, Davis S, Cotman K, Worley S, Londrico D, Kenny D . Feeding difficulties and growth delay in children with hypoplastic left heart syndrome versus d-transposition of the great arteries. Pediatr Cardiol. 2007; 29(2):328-33. DOI: 10.1007/s00246-007-9027-9. View

Spijkerboer A, Utens E, De Koning W, Bogers A, Helbing W, Verhulst F . Health-related Quality of Life in children and adolescents after invasive treatment for congenital heart disease. Qual Life Res. 2006; 15(4):663-73. DOI: 10.1007/s11136-005-3692-z. View

Lim C, Lim J, Moorakonda R, Ong C, Mok Y, Allen J . The Impact of Pre-operative Nutritional Status on Outcomes Following Congenital Heart Surgery. Front Pediatr. 2019; 7:429. PMC: 6820300. DOI: 10.3389/fped.2019.00429. View

Ferentzi H, Pfitzer C, Rosenthal L, Berger F, Schmitt K . Long-term early development research in congenital heart disease (LEADER-CHD): a study protocol for a prospective cohort observational study investigating the development of children after surgical correction for congenital heart defects during the.... BMJ Open. 2017; 7(12):e018966. PMC: 5770821. DOI: 10.1136/bmjopen-2017-018966. View

Apitz C, Webb G, Redington A . Tetralogy of Fallot. Lancet. 2009; 374(9699):1462-71. DOI: 10.1016/S0140-6736(09)60657-7. View

van der Linde D, Konings E, Slager M, Witsenburg M, Helbing W, Takkenberg J . Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011; 58(21):2241-7. DOI: 10.1016/j.jacc.2011.08.025. View

Maymone-Martins F . Tetralogy of Fallot after repair: A heritage of modern cardiac surgery. Rev Port Cardiol (Engl Ed). 2018; 37(9):781-782. DOI: 10.1016/j.repc.2018.08.004. View

MEHRIZI A, DRASH A . Growth disturbance in congenital heart disease. J Pediatr. 1962; 61:418-29. DOI: 10.1016/s0022-3476(62)80373-4. View

Dalili M, Meraji S, Davari P, Moghaddam M, Bakhshandeh Abkenar H, Vahidi A . Growth status of Iranian children with hemodynamically important congenital heart disease. Acta Med Iran. 2011; 49(2):103-8. View

10.

Morgenthau A, Frishman W . Genetic Origins of Tetralogy of Fallot. Cardiol Rev. 2017; 26(2):86-92. DOI: 10.1097/CRD.0000000000000170. View

11.

Medoff-Cooper B, Ravishankar C . Nutrition and growth in congenital heart disease: a challenge in children. Curr Opin Cardiol. 2013; 28(2):122-9. DOI: 10.1097/HCO.0b013e32835dd005. View

12.

Mujica-Coopman M, Navarro-Rosenblatt D, Lopez-Arana S, Corvalan C . Nutrition status in adult Chilean population: economic, ethnic and sex inequalities in a post-transitional country. Public Health Nutr. 2020; 23(S1):s39-s50. PMC: 10200670. DOI: 10.1017/S1368980019004439. View

13.

Di Felice V, Zummo G . Tetralogy of fallot as a model to study cardiac progenitor cell migration and differentiation during heart development. Trends Cardiovasc Med. 2009; 19(4):130-5. DOI: 10.1016/j.tcm.2009.07.004. View

14.

. Egypt 2005: results from the Demographic and Health Survey. Stud Fam Plann. 2007; 37(4):299-304. DOI: 10.1111/j.1728-4465.2006.00108.x. View

15.

Zhao A, Gao H, Li B, Zhang J, Win N, Wang P . Inappropriate Feeding Behavior: One of the Important Causes of Malnutrition in 6- to 36-Month-Old Children in Myanmar. Am J Trop Med Hyg. 2016; 95(3):702-8. PMC: 5014282. DOI: 10.4269/ajtmh.16-0019. View

16.

Okoromah C, Ekure E, Lesi F, Okunowo W, Tijani B, Okeiyi J . Prevalence, profile and predictors of malnutrition in children with congenital heart defects: a case-control observational study. Arch Dis Child. 2011; 96(4):354-60. PMC: 3056291. DOI: 10.1136/adc.2009.176644. View

17.

Ratanachu-Ek S, Pongdara A . Nutritional status of pediatric patients with congenital heart disease: pre- and post cardiac surgery. J Med Assoc Thai. 2011; 94 Suppl 3:S133-7. View

18.

Frozanfar M, Yoshida Y, Yamamoto E, Reyer J, Dalil S, Rahimzad A . Acute malnutrition among under-five children in Faryab, Afghanistan: prevalence and causes. Nagoya J Med Sci. 2016; 78(1):41-53. PMC: 4767513. View

19.

Chen C, Li C, Wang J . Growth and development of children with congenital heart disease. J Adv Nurs. 2004; 47(3):260-9. DOI: 10.1111/j.1365-2648.2004.03090.x. View

20.

Jones L, Griffiths P, Adair L, Norris S, Richter L, Cameron N . A comparison of the socio-economic determinants of growth retardation in South African and Filipino infants. Public Health Nutr. 2008; 11(12):1220-8. PMC: 2939971. DOI: 10.1017/S1368980008002498. View