Brain Stimulation and Brain Lesions Converge on Common Causal Circuits in Neuropsychiatric Disease

Overview

Journal Nat Hum Behav

Specialties Psychology
Social Sciences

Date 2021 Jul 9

PMID 34239076

Citations 83

Authors

Shan H Siddiqi

Frederic L W V J Schaper

Andreas Horn

Joey Hsu

Jaya L Padmanabhan

Amy Brodtmann

Robin F H Cash

Maurizio Corbetta

Ki Sueng Choi

Darin D Dougherty

Natalia Egorova

Paul B Fitzgerald

Mark S George

Sophia A Gozzi

Frederike Irmen

Andrea A Kuhn

Kevin A Johnson

Andrew M Naidech

Alvaro Pascual-Leone

Thanh G Phan

Rob P W Rouhl

Stephan F Taylor

Joel L Voss

Andrew Zalesky

Jordan H Grafman

Helen S Mayberg

Michael D Fox

Affiliations

Soon will be listed here.

Abstract

Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep brain stimulation (n = 101, five datasets). Lesions and stimulation sites most associated with depression severity were connected to a similar brain circuit across all 14 datasets (P < 0.001). Circuits derived from lesions, deep brain stimulation and transcranial magnetic stimulation were similar (P < 0.0005), as were circuits derived from patients with major depression versus other diagnoses (P < 0.001). Connectivity to this circuit predicted out-of-sample antidepressant efficacy of transcranial magnetic stimulation and deep brain stimulation sites (P < 0.0001). In an independent analysis, 29 lesions and 95 stimulation sites converged on a distinct circuit for motor symptoms of Parkinson's disease (P < 0.05). We conclude that lesions, transcranial magnetic stimulation and DBS converge on common brain circuitry that may represent improved neurostimulation targets for depression and other disorders.

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