Auditory Brainstem Responses in Adults with Autism Spectrum Disorder

Overview

Journal Clin Neurophysiol Pract

Publisher Elsevier

Specialty Neurology

Date 2021 Jul 8

PMID 34235293

Citations 4

Authors

H Fujihira

C Itoi

S Furukawa

N Kato

M Kashino

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate possible differences in the auditory peripheral and brainstem functions between adults with autism spectrum disorder (ASD) and neurotypical (NT) adults.

Methods: Click-evoked auditory brainstem responses (ABRs) were obtained from 17 high-functioning ASD adults (aged 21-38 years) and 20 NT adults (aged 22-36 years). A relatively large number of stimulus presentations (6000) were adopted, and ABRs by horizontal and vertical electrode montages were evaluated, in order to allow precise evaluations of early ABR components.

Results: Waves I, II, III, and V were identified in the vertical electrode montage, and wave I and the summating potential (SP) in electrocochleograms were identified in the horizontal electrode montage. There were no significant group differences in the wave I, II, III, and V latencies or the interpeak latencies (IPLs) in the vertical electrode montage. In the horizontal montage, the ASD adults exhibited significantly shortened SP latencies compared with the NT adults, whereas there was no significant group difference in the wave I latency.

Conclusion: The ASD adults may have the abnormalities of processing more in the peripheral auditory system than in the brainstem.

Significance: The current study suggests that the peripheral abnormality is associated with ASD.

Citing Articles

Association Analysis of Rare CNTN5 Variants With Autism Spectrum Disorder in a Japanese Population.

Hadi A, Arta R, Kushima I, Egawa J, Watanabe Y, Ozaki N Neuropsychopharmacol Rep. 2025; 45(1):e12527.

PMID: 39887962 PMC: 11781355. DOI: 10.1002/npr2.12527.

How auditory processing influences the autistic profile: A review.

Poulsen R, Williams Z, Dwyer P, Pellicano E, Sowman P, McAlpine D Autism Res. 2024; 17(12):2452-2470.

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Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wild-type and Neurexin1α knockout rats.

Marashli S, Janz P, Redondo R BMC Neurosci. 2024; 25(1):18.

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Auditory Brainstem Response in Autistic Children: Implications for Sensory Processing.

Cardon G, Cate M, Cordingley S, Bown B Hearing Balance Commun. 2024; 21(3):224-232.

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Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing.

Goncalves A, Monteiro P J Neural Transm (Vienna). 2023; 130(3):325-408.

PMID: 36914900 PMC: 10033482. DOI: 10.1007/s00702-023-02595-9.

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