Single-cell Profiling Reveals the Dynamics of Cytomegalovirus-specific T Cells in Haploidentical Hematopoietic Stem Cell Transplantation

Overview

Journal Haematologica

Specialty Hematology

Date 2021 Jul 8

PMID 34233445

Citations 4

Authors

Jasper J P van Beek

Simone Puccio

Alessandra Roberto

Federica De Paoli

Giulia Graziano

Elisa Salviato

Giorgia Alvisi

Veronica Zanon

Alice Scarpa

Elisa Zaghi

Michela Calvi

Clara Di Vito

Rossana Mineri

Barbara Sarina

Chiara De Philippis

Armando Santoro

Jacopo Mariotti

Stefania Bramanti

Francesco Ferrari

Luca Castagna

Domenico Mavilio

Enrico Lugli

Affiliations

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Citing Articles

Circulating cytokine and chemokine patterns associated with cytomegalovirus reactivation after stem cell transplantation.

Stern L, McGuire H, Avdic S, Blyth E, Gottlieb D, Patrick E Clin Transl Immunology. 2023; 12(12):e16815.

PMID: 38034080 PMC: 10684332. DOI: 10.1002/cti2.1473.

Selected memory T cells infused post-haploidentical hematopoietic stem cell transplantation persist and hyperexpand.

van Beek J, Puccio S, Di Vito C, De Paoli F, Zaghi E, Calvi M Blood Adv. 2022; 7(14):3458-3468.

PMID: 36469095 PMC: 10362279. DOI: 10.1182/bloodadvances.2022007735.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).

Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M Eur J Immunol. 2021; 51(12):2708-3145.

PMID: 34910301 PMC: 11115438. DOI: 10.1002/eji.202170126.

CMV Infection and CMV-Specific Immune Reconstitution Following Haploidentical Stem Cell Transplantation: An Update.

Luo X, Zhu Y, Chen Y, Shui L, Liu L Front Immunol. 2021; 12:732826.

PMID: 34777342 PMC: 8580860. DOI: 10.3389/fimmu.2021.732826.

References

Cieri N, Oliveira G, Greco R, Forcato M, Taccioli C, Cianciotti B . Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation. Blood. 2015; 125(18):2865-74. DOI: 10.1182/blood-2014-11-608539. View

Suessmuth Y, Mukherjee R, Watkins B, Koura D, Finstermeier K, Desmarais C . CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire. Blood. 2015; 125(25):3835-50. PMC: 4473113. DOI: 10.1182/blood-2015-03-631853. View

Crocchiolo R, Bramanti S, Vai A, Sarina B, Mineri R, Casari E . Infections after T-replete haploidentical transplantation and high-dose cyclophosphamide as graft-versus-host disease prophylaxis. Transpl Infect Dis. 2015; 17(2):242-9. PMC: 7169814. DOI: 10.1111/tid.12365. View

Levine J, Simonds E, Bendall S, Davis K, Amir E, Tadmor M . Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis. Cell. 2015; 162(1):184-97. PMC: 4508757. DOI: 10.1016/j.cell.2015.05.047. View

Wills M, Carmichael A, Mynard K, Jin X, Weekes M, Plachter B . The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol. 1996; 70(11):7569-79. PMC: 190825. DOI: 10.1128/JVI.70.11.7569-7579.1996. View

Anderson B, McNiff J, Yan J, Doyle H, Mamula M, Shlomchik M . Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest. 2003; 112(1):101-8. PMC: 162285. DOI: 10.1172/JCI17601. View

Wachsmuth L, Patterson M, Eckhaus M, Venzon D, Gress R, Kanakry C . Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression. J Clin Invest. 2019; 129(6):2357-2373. PMC: 6546453. DOI: 10.1172/JCI124218. View

Huntley D, Gimenez E, Pascual M, Remigia M, Amat P, Vazquez L . Reconstitution of cytomegalovirus-specific T-cell immunity following unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide. Bone Marrow Transplant. 2020; 55(7):1347-1356. DOI: 10.1038/s41409-020-0865-x. View

Pelak O, Stuchly J, Krol L, Hubacek P, Keslova P, Sedlacek P . Appearance of cytomegalovirus-specific T-cells predicts fast resolution of viremia post hematopoietic stem cell transplantation. Cytometry B Clin Cytom. 2015; 92(5):380-388. DOI: 10.1002/cyto.b.21348. View

10.

Camargo J, Wieder E, Kimble E, Benjamin C, Kolonias D, Kwon D . Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation. Blood. 2018; 133(8):867-877. DOI: 10.1182/blood-2018-10-878918. View

11.

Kanakry C, Ganguly S, Zahurak M, Bolanos-Meade J, Thoburn C, Perkins B . Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Sci Transl Med. 2013; 5(211):211ra157. PMC: 4155575. DOI: 10.1126/scitranslmed.3006960. View

12.

Chen B, Deoliveira D, Cui X, Le N, Son J, Whitesides J . Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. Blood. 2006; 109(7):3115-23. PMC: 1852216. DOI: 10.1182/blood-2006-04-016410. View

13.

Kanakry C, Coffey D, Towlerton A, Vulic A, Storer B, Chou J . Origin and evolution of the T cell repertoire after posttransplantation cyclophosphamide. JCI Insight. 2016; 1(5). PMC: 4874509. DOI: 10.1172/jci.insight.86252. View

14.

Luznik L, ODonnell P, Symons H, Chen A, Leffell M, Zahurak M . HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008; 14(6):641-50. PMC: 2633246. DOI: 10.1016/j.bbmt.2008.03.005. View

15.

Roberto A, Castagna L, Zanon V, Bramanti S, Crocchiolo R, McLaren J . Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood. 2015; 125(18):2855-64. PMC: 4424633. DOI: 10.1182/blood-2014-11-608406. View