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Optical Coherence Tomography Angiography of Choroidal Nodules in Neurofibromatosis Type-1: A Case Series

Overview
Journal Eur J Ophthalmol
Specialty Ophthalmology
Date 2021 Jul 7
PMID 34231401
Citations 5
Authors
Francisco Javier Moreno-Morillo
Jose Ignacio Fernandez-Vigo
Barbara Burgos-Blasco
Carlos Llorente-la Orden
Beatriz Vidal-Villegas
Enrique Santos-Bueso
Affiliations
Soon will be listed here.
Abstract

Purpose: To describe optical coherence tomography angiography (OCTA) findings in the retina and choroid of patients with neurofibromatosis type 1 (NF1).

Methods: We describe a series of four patients diagnosed with NF1 and choroidal nodules who underwent a comprehensive ophthalmic evaluation including a retinal multimodal imaging study based on retinography, near-infrared reflectance imaging (NIR), enhanced depth imaging (EDI) optical coherence tomography (OCT) and OCTA.

Results: Patients were three women and one man aged 36-47 years. In all patients, the choroidal nodules were not visible in retinographies but easily detectable with NIR, appearing as multiple bright patches. On OCTA, we observed reduced vessel density in the choriocapillaris in zones where choroidal nodules appeared in OCT images. In one patient, a corkscrew vessel was visible in the superficial capillary plexus.

Conclusion: Choriocapillaris vessel density was reduced in zones where choroidal nodules occur in NF1 patients. Further work is needed to clarify the clinical relevance of this finding.

Citing Articles

Neurofibromatosis Type 1-Retinal Alterations Detectable with Optical Coherence Tomography Angiography.

Tartea A, Mocanu C, Stefanescu Dima A, Tanasie A, Maria V, Dan A Diagnostics (Basel). 2024; 14(13).

PMID: 39001337 PMC: 11240892. DOI: 10.3390/diagnostics14131447.

Insights into Novel Choroidal and Retinal Clinical Signs in Neurofibromatosis Type 1.

Mallone F, Alisi L, Lucchino L, Di Martino V, Nebbioso M, Armentano M Int J Mol Sci. 2023; 24(17).

PMID: 37686284 PMC: 10488231. DOI: 10.3390/ijms241713481.

Choroidal Hyperreflective Nodules Detected by Infrared Reflectance Images Are a Diagnostic Criterion for Neurofibromatosis Type 1 Patients Excluding Those with High Myopia.

Orejudo de Rivas M, Gabas J, Cabeza M, Esteban Floria O, Latorre R, Moscarda E Diagnostics (Basel). 2023; 13(7).

PMID: 37046566 PMC: 10093036. DOI: 10.3390/diagnostics13071348.

Intervortex Venous Anastomosis in the Macula in Central Serous Chorioretinopathy Imaged by En Face Optical Coherence Tomography.

Fernandez-Vigo J, Rego-Lorca D, Moreno-Morillo F, Burgos-Blasco B, Valverde-Megias A, Mendez-Hernandez C J Clin Med. 2023; 12(6).

PMID: 36983092 PMC: 10052017. DOI: 10.3390/jcm12062088.

An update on choroidal abnormalities and retinal microvascular changes in neurofibromatosis type 1.

Mallone F, Lucchino L, Giustini S, Lambiase A, Moramarco A Orphanet J Rare Dis. 2022; 17(1):223.

PMID: 35698197 PMC: 9195315. DOI: 10.1186/s13023-022-02369-8.

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