Genetic Analysis of Human Parainfluenza Virus Type 4 Associated with Severe Acute Respiratory Infection in Children in Luohe City, Henan Province, China, During 2017-2018

Overview

Journal Arch Virol

Specialty Microbiology

Date 2021 Jul 7

PMID 34231027

Citations 2

Authors

Shanshan Zhou

Naiying Mao

Yan Zhang

Aili Cui

Zhen Zhu

Ruiping Hu

Jin Xu

Wenbo Xu

Affiliations

Soon will be listed here.

Abstract

During 2017-2018, nasopharyngeal aspirates (NPAs) from 627 hospitalized patients with severe acute respiratory infection at Luohe Center Hospital were tested by RT-PCR for human parainfluenza virus 4 (HPIV-4). Fourteen (2.2%) of the 627 samples were positive for HPIV-4. The complete HN gene was amplified from nine positive samples and sequenced. Sequence comparisons showed that the HPIV-4 strains circulating in the city of Luohe are closely related to HPIV-4A strains. Our study indicated that there were multiple lineages of HPIV-4 circulating in Henan Province in China during the study period. This will improve our understanding of the epidemiological and clinical characteristics of HPIV-4.

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