Leptin Expression is Substantially Correlated with Prognosis of Urinary Bladder Carcinoma

Overview

Journal Libyan J Med

Specialty General Medicine

Date 2021 Jul 7

PMID 34229569

Authors

Mohamad Nidal Khabaz

Imtiaz Ahmad Qureshi

Jaudah Ahmad Al-Maghrabi

Affiliations

Soon will be listed here.

Abstract

This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies.A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays.Leptin was up-regulated during transformation and was identified as brown cytoplasmic granules in the malignant urothelium of 123 (96%) bladder neoplasms, of which 68 (53.1%) cases showed high levels (moderate to strong) of staining. Strong staining was found to be associated with high stages (P = 0.001), muscularis propria infiltration (P < 0.001), vascular invasion (P < 0.03), lymph node involvement (P < 0.02), metastases (P < 0.05), and mortality (P < 0.03). Furthermore, various important survival distributions were detected with leptin expression in the malignant urothelium (P < 0.03).These pilot results suggest that leptin might be a valid marker for predicting the stage and bad prognoses in bladder carcinoma.

References

Al-Maghrabi J, Emam E, Gomaa W, Saggaf M, Buhmeida A, Al-Qahtani M . c-MET immunostaining in colorectal carcinoma is associated with local disease recurrence. BMC Cancer. 2015; 15:676. PMC: 4603921. DOI: 10.1186/s12885-015-1662-6. View

Kelloff G, Sigman C, Scher H . Biomarker development in the context of urologic cancers. Urol Oncol. 2015; 33(6):295-301. PMC: 4521394. DOI: 10.1016/j.urolonc.2015.01.007. View

Ogunwobi O, Beales I . Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells. Dig Dis Sci. 2007; 52(8):1934-45. DOI: 10.1007/s10620-007-9784-6. View

Gallina S, Sireci F, Lorusso F, DI Benedetto D, Speciale R, Marchese D . The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma. Acta Otorhinolaryngol Ital. 2015; 35(1):15-22. PMC: 4443575. View

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J . Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372(6505):425-32. DOI: 10.1038/372425a0. View

Fan Y, Li X . Expression of leptin and its receptor in thyroid carcinoma: distinctive prognostic significance in different subtypes. Clin Endocrinol (Oxf). 2014; 83(2):261-7. DOI: 10.1111/cen.12598. View

Jeong W, Baek S, Kim M, Kwon S, Kim H . Prognostic Significance of Tissue Leptin Expression in Colorectal Cancer Patients. Ann Coloproctol. 2016; 31(6):222-7. PMC: 4724703. DOI: 10.3393/ac.2015.31.6.222. View

Carino C, Olawaiye A, Cherfils S, Serikawa T, Lynch M, Rueda B . Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells. Int J Cancer. 2008; 123(12):2782-90. PMC: 2892183. DOI: 10.1002/ijc.23887. View

Prout Jr G, Barton B, Griffin P, FRIEDELL G . Treated history of noninvasive grade 1 transitional cell carcinoma. The National Bladder Cancer Group. J Urol. 1992; 148(5):1413-9. DOI: 10.1016/s0022-5347(17)36924-0. View

10.

Baratta M . Leptin--from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit. 2002; 8(12):RA282-92. View

11.

Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau J, Bortoluzzi M . The stomach is a source of leptin. Nature. 1998; 394(6695):790-3. DOI: 10.1038/29547. View

12.

Duan X, Tang P, Zhang H, Yu Z . [Expression of leptin and adiponectin in esophageal squamous cell carcinoma and their clinical significance]. Zhonghua Zhong Liu Za Zhi. 2015; 36(11):839-43. View

13.

Caro J, Sinha M, Kolaczynski J, Zhang P, Considine R . Leptin: the tale of an obesity gene. Diabetes. 1996; 45(11):1455-62. DOI: 10.2337/diab.45.11.1455. View

14.

Riolfi M, Ferla R, Del Valle L, Pina-Oviedo S, Scolaro L, Micciolo R . Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol. 2009; 20(2):481-9. PMC: 2864337. DOI: 10.1111/j.1750-3639.2009.00323.x. View

15.

Zhou X, Li H, Chai Y, Liu Z . Leptin Inhibits the Apoptosis of Endometrial Carcinoma Cells Through Activation of the Nuclear Factor κB-inducing Kinase/IκB Kinase Pathway. Int J Gynecol Cancer. 2015; 25(5):770-8. DOI: 10.1097/IGC.0000000000000440. View

16.

Bartucci M, Svensson S, Ricci-Vitiani L, Dattilo R, Biffoni M, Signore M . Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells. Endocr Relat Cancer. 2010; 17(3):823-33. DOI: 10.1677/ERC-10-0083. View

17.

Geng Y, Wang J, Wang R, Wang K, Xu Y, Song G . Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients. Biomed Pharmacother. 2012; 66(6):419-24. DOI: 10.1016/j.biopha.2012.03.002. View

18.

Siegel R, Miller K, Jemal A . Cancer statistics, 2020. CA Cancer J Clin. 2020; 70(1):7-30. DOI: 10.3322/caac.21590. View

19.

Lee K, Choi H, Yang S, Park H, Lee Y, Lee O . The role of leptin in gastric cancer: clinicopathologic features and molecular mechanisms. Biochem Biophys Res Commun. 2014; 446(4):822-9. DOI: 10.1016/j.bbrc.2014.02.072. View

20.

Jemal A, Bray F, Center M, Ferlay J, Ward E, Forman D . Global cancer statistics. CA Cancer J Clin. 2011; 61(2):69-90. DOI: 10.3322/caac.20107. View