Mammalian Tracheal Development and Reconstruction: Insights from in Vivo and in Vitro Studies

Overview

Journal Development

Specialty Biology

Date 2021 Jul 6

PMID 34228796

Citations 10

Authors

Keishi Kishimoto

Mitsuru Morimoto

Affiliations

Soon will be listed here.

Abstract

The trachea delivers inhaled air into the lungs for gas exchange. Anomalies in tracheal development can result in life-threatening malformations, such as tracheoesophageal fistula and tracheomalacia. Given the limitations of current therapeutic approaches, development of technologies for the reconstitution of a three-dimensional trachea from stem cells is urgently required. Recently, single-cell sequencing technologies and quantitative analyses from cell to tissue scale have been employed to decipher the cellular basis of tracheal morphogenesis. In this Review, recent advances in mammalian tracheal development and the generation of tracheal tissues from pluripotent stem cells are summarized.

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