[Hidradenitis Suppurativa /acne Inversa-surgical Options, Reconstruction and Combinations with Drug Therapies-an Update]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2021 Jul 6

PMID 34228137

Citations 3

Authors

P Cramer

S Schneider-Burrus

M Kovacs

L Scholl

M Podda

F G Bechara

Affiliations

Soon will be listed here.

Abstract

Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease whose treatment includes both conservative and surgical treatment options. In Hurley stages II and III, surgical resection of irreversibly destroyed tissue should be the objective. For this purpose several resection techniques exist, which differ primarily with regard to their invasiveness and tendency to recur. To date, there is no generally accepted consensus on the use of different resection and reconstruction techniques or the inclusion of drug therapies in the overall therapeutic concept.

Citing Articles

[Hidradenitis suppurativa].

Alter M Dermatologie (Heidelb). 2024; 75(6):497-506.

PMID: 38512397 DOI: 10.1007/s00105-024-05321-y.

Current Medical and Surgical Treatment of Hidradenitis Suppurativa-A Comprehensive Review.

Ocker L, Abu Rached N, Seifert C, Scheel C, Bechara F J Clin Med. 2022; 11(23).

PMID: 36498816 PMC: 9737445. DOI: 10.3390/jcm11237240.

[Hidradenitis suppurativa/acne inversa: From "orphan disease" to a curable inflammatory skin disorder].

Zouboulis C, von Stebut E Hautarzt. 2021; 72(8):647-650.

PMID: 34324067 DOI: 10.1007/s00105-021-04863-9.

References

Savage K, Brant E, Rosales Santillan M, Morss P, Salian P, Flood K . Methotrexate shows benefit in a subset of patients with severe hidradenitis suppurativa. Int J Womens Dermatol. 2020; 6(3):159-163. PMC: 7330449. DOI: 10.1016/j.ijwd.2020.02.007. View

Humphries L, Kueberuwa E, Beederman M, Gottlieb L . Wide excision and healing by secondary intent for the surgical treatment of hidradenitis suppurativa: A single-center experience. J Plast Reconstr Aesthet Surg. 2016; 69(4):554-66. DOI: 10.1016/j.bjps.2015.12.004. View

Anderson B, Cadogan C, GANGADHARAM D . Hidradenitis suppurativa of the perineum, scrotum, and gluteal area: presentation, complications, and treatment. J Natl Med Assoc. 1982; 74(10):999-1003. PMC: 2561391. View

Martorell A, Giovanardi G, Gomez-Palencia P, Sanz-Motilva V . Defining Fistular Patterns in Hidradenitis Suppurativa: Impact on the Management. Dermatol Surg. 2019; 45(10):1237-1244. DOI: 10.1097/DSS.0000000000001916. View

van Rappard D, Mekkes J . Treatment of severe hidradenitis suppurativa with infliximab in combination with surgical interventions. Br J Dermatol. 2012; 167(1):206-8. DOI: 10.1111/j.1365-2133.2012.10807.x. View

Kerdel F, Azevedo F, Kerdel Don C, Don F, Fabbrocini G, Kerdel F . Apremilast for the Treatment of Mild-to-Moderate Hidradenitis Suppurativa in a Prospective, Open-Label, Phase 2 Study. J Drugs Dermatol. 2019; 18(2):170-176. View

Patel Z, Hoffman L, Buse D, Grinberg A, Afifi L, Cohen S . Pain, Psychological Comorbidities, Disability, and Impaired Quality of Life in Hidradenitis Suppurativa [corrected]. Curr Pain Headache Rep. 2017; 21(12):49. PMC: 5784845. DOI: 10.1007/s11916-017-0647-3. View

Kovacs M, Podda M . Guselkumab in the treatment of severe hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2018; 33(3):e140-e141. DOI: 10.1111/jdv.15368. View

Ingram J, Collier F, Brown D, Burton T, Burton J, Chin M . British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018. Br J Dermatol. 2018; 180(5):1009-1017. DOI: 10.1111/bjd.17537. View

10.

Ariyan S, Krizek T . Hidradenitis suppurativa of the groin, treated by excision and spontaneous healing. Plast Reconstr Surg. 1976; 58(1):44-7. DOI: 10.1097/00006534-197607000-00007. View

11.

Jemec G . Clinical practice. Hidradenitis suppurativa. N Engl J Med. 2012; 366(2):158-64. DOI: 10.1056/NEJMcp1014163. View

12.

Grimstad O, Tzellos T, Dufour D, Bremnes O, Skoie I, Snekvik I . Evaluation of medical and surgical treatments for hidradenitis suppurativa using real-life data from the Scandinavian registry (HISREG). J Eur Acad Dermatol Venereol. 2018; 33(6):1164-1171. DOI: 10.1111/jdv.15353. View

13.

Jemec G, Okun M, Forman S, Gulliver W, Prens E, Mrowietz U . Adalimumab medium-term dosing strategy in moderate-to-severe hidradenitis suppurativa: integrated results from the phase III randomized placebo-controlled PIONEER trials. Br J Dermatol. 2019; 181(5):967-975. PMC: 6899827. DOI: 10.1111/bjd.17919. View

14.

Hughes L . Pathogenesis, clinical features and management of hidradenitis suppurativa. Ann R Coll Surg Engl. 1997; 79(4):309-10. PMC: 2502826. View

15.

Albrecht J, Baine P, Ladizinski B, Jemec G, Bigby M . Long-term clinical safety of clindamycin and rifampicin combination for the treatment of hidradenitis suppurativa. A Critically Appraised Topic. Br J Dermatol. 2018; 180(4):749-755. DOI: 10.1111/bjd.17265. View

16.

Altmann S, Fansa H, Schneider W . [Surgical treatment of axillary hidradenitis suppurativa]. Chirurg. 2002; 72(12):1413-6. DOI: 10.1007/s001040170004. View

17.

Hazen P, Hazen B . Hidradenitis suppurativa: successful treatment using carbon dioxide laser excision and marsupialization. Dermatol Surg. 2009; 36(2):208-13. DOI: 10.1111/j.1524-4725.2009.01427.x. View

18.

Dahmen R, Gkalpakiotis S, Mardesicova L, Arenberger P, Arenbergerova M . Deroofing followed by thorough sinus tract excision: a modified surgical approach for hidradenitis suppurativa. J Dtsch Dermatol Ges. 2019; 17(7):698-702. DOI: 10.1111/ddg.13875. View

19.

Kagan R, Yakuboff K, Warner P, Warden G . Surgical treatment of hidradenitis suppurativa: a 10-year experience. Surgery. 2005; 138(4):734-40. DOI: 10.1016/j.surg.2005.06.053. View

20.

Zouboulis C, Desai N, Emtestam L, Hunger R, Ioannides D, Juhasz I . European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa. J Eur Acad Dermatol Venereol. 2015; 29(4):619-44. DOI: 10.1111/jdv.12966. View