Expression of the Insulin-like Growth Factor II Gene in the Choroid Plexus and the Leptomeninges of the Adult Rat Central Nervous System

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1988 Jan 1

PMID 3422410

Citations 45

Authors

F Stylianopoulou

J Herbert

M B Soares

A Efstratiadis

Affiliations

Soon will be listed here.

Abstract

The rat insulin-like growth factor II gene, encoding a fetal somatomedin, expresses a multitranscript family in embryonic/fetal tissues and in the adult brain and spinal cord. By performing in situ hybridization on tissue sections of adult brain and spinal cord, we have found that these transcripts are not expressed in neural or glial cells but are expressed in the epithelium of the choroid plexus of each cerebral ventricle and in the leptomeninges. We propose that the choroidal epithelial cells synthesize and secrete insulin-like growth factor II into the cerebrospinal fluid.

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