Research on the Glial-Lymphatic System and Its Relationship With Alzheimer's Disease

Overview

Journal Front Neurosci

Date 2021 Jul 5

PMID 34220413

Citations 4

Authors

Danhua Ding

Xinyu Wang

Qianqian Li

Lanjun Li

Jun Wu

Affiliations

Soon will be listed here.

Abstract

Metabolic waste clearance is essential to maintain body homeostasis, in which the lymphatic system plays a vital role. Conversely, in recent years, studies have identified the glial-lymphatic system in the brain, which primarily comprises the inflow of fluid along the para-arterial space. Aquaporin-4 mediates the convection of interstitial fluid in the brain and outflow along the paravenous space. β-Amyloid deposition is a characteristic pathological change in Alzheimer's disease, and some studies have found that the glial-lymphatic system plays an important role in its clearance. Thus, the glial-lymphatic system may influence Alzheimer's disease severity and outcome; therefore, this review summarizes the current and available research on the glial-lymphatic system and Alzheimer's disease.

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