Overcome the Barriers of the Skin: Exosome Therapy

Overview

Journal Biomater Res

Specialty Biomedical Engineering

Date 2021 Jul 4

PMID 34217362

Citations 29

Authors

Gi Hoon Yang

Yoon Bum Lee

Donggu Kang

Eunjeong Choi

Yoonju Nam

Kyoung Ho Lee

Hi-Jin You

Hyo Jin Kang

Sang Hyun An

Hojun Jeon

Affiliations

Soon will be listed here.

Abstract

Exosomes are nano-sized cargos with a lipid bilayer structure carrying diverse biomolecules including lipids, proteins, and nucleic acids. These small vesicles are secreted by most types of cells to communicate with each other. Since exosomes circulate through bodily fluids, they can transfer information not only to local cells but also to remote cells. Therefore, exosomes are considered potential biomarkers for various treatments. Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wounds. Also, exosomes are being studied to be used as ingredients in commercialized skin treatment products. In this review, we discussed the need for exosomes in skin therapy together with the current challenges. Moreover, the functional roles of exosomes in terms of skin treatment and regeneration are overviewed. Finally, we highlighted the major limitations and the future perspective in exosome engineering.

Citing Articles

Exploring the Therapeutic Potential of Extracellular Vesicles Anchored to the Sea Cucumber Extracellular Matrix for Treating Atopic Dermatitis.

Jo S, Kim S, Heo S, Cho H, Esfahani I, Park S Biomater Res. 2025; 29:0154.

PMID: 39990978 PMC: 11842673. DOI: 10.34133/bmr.0154.

The Role of Exosomes in Medical Dermatology: Literature Review and Update.

Dukharan V, Shah M, Broughton L, Stegura C, Samman L, Schur N J Cosmet Dermatol. 2025; 24(1):e16761.

PMID: 39797525 DOI: 10.1111/jocd.16761.

Clinical applications of exosomes in cosmetic dermatology.

Bai G, Truong T, Pathak G, Benoit L, Rao B Skin Health Dis. 2024; 4(6):e348.

PMID: 39624733 PMC: 11608875. DOI: 10.1002/ski2.348.

Exosomes from Ameliorate Benzalkonium Chloride-Induced Inflammation in Conjunctival Cells.

Lee K, Gwon H, Kim J, Shim J, Lee J Int J Mol Sci. 2024; 25(22).

PMID: 39596346 PMC: 11595052. DOI: 10.3390/ijms252212282.

Topical Wharton's Jelly MSC-Derived Age Zero™ Exosome Treatments After Micro-Needling for Skin Rejuvenation.

Cicchetti C, Mazzeo C, Heke M, Crowley M, Ntonos A, Crowley E J Cosmet Dermatol. 2024; 23(12):4389-4391.

PMID: 39367640 PMC: 11626297. DOI: 10.1111/jocd.16561.

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