MicroRNAs in Axial Spondylarthritis: an Overview of the Recent Progresses in the Field with a Focus on Ankylosing Spondylitis and Psoriatic Arthritis

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2021 Jul 3

PMID 34216293

Citations 6

Authors

Francesca Motta

Andrea Pederzani

Maria Cristina Carena

Angela Ceribelli

Paul B Wordsworth

Maria De Santis

Carlo Selmi

Matteo Vecellio

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: To highlight the recent discoveries and lines of evidence on the role of microRNAs in ankylosing spondylitis (AS) and psoriatic arthritis (PsA), focusing on their expression profiling and mechanisms of action.

Recent Findings: AS and PsA are chronic inflammatory musculoskeletal diseases with axial manifestations and represent an excellent model for studying microRNAs contribution to the disease pathogenesis, particularly through immunomodulation, inflammation, and bone remodelling, or their value as candidate diagnostic and prognostic biomarkers. MicroRNAs are single-stranded nucleotides able to regulate gene expression. They are a key component of the epigenetic machinery, involved in physiological and pathological processes. The contribution of microRNAs in AS and PsA (such as miR-29a in regulating bone metabolism) is highlighted by several works in the field but their utility as possible markers must be still confirmed, particularly in larger patients' cohorts.

Citing Articles

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Differences between psoriatic arthritis and psoriasis in multi-omics.

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Assessment of Circulating lncRNA H19 in Ankylosing Spondylitis Patients and Its Correlation with Disease Activity.

Esawy M, Ebaid A, Abd-Elhameed A, Thagfan F, Mubaraki M, Alazzouni A J Pers Med. 2023; 13(6).

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Zhang X, Chen T, Qian X, He X Comput Math Methods Med. 2023; 2023:9065561.

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