Repair Calvarial Defect of Osteoporotic Rats by Berberine Functionalized Porous Calcium Phosphate Scaffold

Overview

Journal Regen Biomater

Specialty Biomedical Engineering

Date 2021 Jul 2

PMID 34211732

Citations 12

Authors

Dahao Wang

Peng Zhang

Xifan Mei

Zhenhua Chen

Affiliations

Soon will be listed here.

Abstract

In this article, we propose a simple scheme of using berberine (BBR) to modify porous calcium phosphate ceramics (named PCPC). These BBR molecules regulate the crystallization of hydroxyapatite nanorods on PCPC. We found that these nanorods and the adsorbed BBR changed the interface micro-environment of PCPC by SEM images. The microenvironment of PCPC surface is essential for promoting BMSCs' proliferation and differentiation. These results demonstrated that PCPC/BBR markedly improved the bone regeneration of osteoporosis rats. Moreover, PCPC/BBR had significantly increased the expression levels of ALP, osteocalcin and bone morphogenetic protein2 and RUNX2 in BMSCs originated from osteoporosis rats.

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