Antimicrobial Resistance and Genomic Characterization of Two -Harboring Foodborne Isolates Recovered in China, 2016

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2021 Jul 2

PMID 34211439

Citations 4

Authors

Yujie Hu

Scott V Nguyen

Wei Wang

Xin Gan

Yinping Dong

Chang Liu

Xinnan Cui

Jin Xu

Fengqin Li

Seamus Fanning

Affiliations

Soon will be listed here.

Abstract

The gene mediating mobile colistin resistance in was first reported in China in 2016 followed by reports among different species worldwide, especially in and . However, data on its transmission in are still lacking. This study analyzed the antimicrobial resistance (AMR) profiles and the gene presence in 755 foodborne from 26 provinces of mainland, China in 2016. Genomic features of two carrying isolates, genome sequencing, serotypes and further resistance profiles were studied. Among the 755 tested, 72.6% were found to be resistant to at least one antimicrobial agent and 10% were defined as multi-drug resistant (MDR). Derby CFSA231 and Typhimurium CFSA629 were -harboring isolates. Both expressed an MDR phenotype and included a single circular chromosome and one plasmid. Among the 22 AMR genes identified in . Derby CFSA231, only the gene was localized on the IncX4 type plasmid pCFSA231 while 20 chromosomal AMR genes, including four plasmid-mediated quinolone resistance (PMQR) genes, were mapped within a 64 kb genomic island (SGI) like region. . Typhimurium CFSA629 possessed 11 resistance genes including an variant and two ESBL genes. Two IS-flanked composite-like transposons were identified. Additionally, 153 and 152 virulence factors were separately identified in these two isolates with secretion system and fimbrial adherence determinants as the dominant virulence classes. Our study extends our concern on -carrying in regards to antimicrobial resistance and virulence factors, and highlight the importance of surveillance to mitigate dissemination of -encoding genes among foodborne .

Citing Articles

The Occurrence and Genomic Characteristics of -Harboring from Retail Meats and Eggs in Qingdao, China.

Li C, Gu X, Zhang L, Liu Y, Li Y, Zou M Foods. 2022; 11(23).

PMID: 36496661 PMC: 9739812. DOI: 10.3390/foods11233854.

Antimicrobial resistance of Indiana from retail chickens in China and emergence of an -harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin.

Hu Y, He Y, Nguyen S, Liu C, Gan X, Wang W Front Microbiol. 2022; 13:955827.

PMID: 36160190 PMC: 9493365. DOI: 10.3389/fmicb.2022.955827.

Genomic Characterization of Two Isolates Harboring Gene From Farm Environment.

Liu R, Xu H, Guo X, Liu S, Qiao J, Ge H Front Cell Infect Microbiol. 2022; 12:774494.

PMID: 35719362 PMC: 9204285. DOI: 10.3389/fcimb.2022.774494.

Mobile Colistin Resistance Genetic Determinants of Non-Typhoid Isolates from Russia.

Kuleshov K, Pavlova A, Shedko E, Mikhaylova Y, Margos G, Hepner S Microorganisms. 2021; 9(12).

PMID: 34946117 PMC: 8705591. DOI: 10.3390/microorganisms9122515.

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