Ending the Neglect of Treatable Bacterial Zoonoses Responsible for Non-Malaria Fevers
Overview
Affiliations
Bacterial zoonotic diseases such as leptospirosis, Q fever, melioidosis, spotted fever group rickettsioses, and brucellosis are increasingly recognized causes of non-malaria acute fevers. However, though readily treatable with antibiotics, these diseases are commonly misdiagnosed resulting in poor outcomes in patients. There is a considerable deficit in the understanding of basic aspects of the epidemiology of these neglected diseases and diagnostic tests for these zoonotic bacterial pathogens are not always available in resource-poor settings. Raising awareness about these emerging bacterial zoonoses is directly beneficial to the patients by allowing a test-and-treat approach and is essential to control these life-threatening diseases.
Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.
Munoz-Zanzi C, Dreyfus A, Limothai U, Foley W, Srisawat N, Picardeau M Open Forum Infect Dis. 2025; 12(2):ofaf035.
PMID: 39963696 PMC: 11832045. DOI: 10.1093/ofid/ofaf035.
Paz L, de Moraes L, Santos L, Hamond C, Pinna M Heliyon. 2025; 11(1):e41531.
PMID: 39834437 PMC: 11742847. DOI: 10.1016/j.heliyon.2024.e41531.
Evolutionary insights into the emergence of virulent Leptospira spirochetes.
Giraud-Gatineau A, Nieves C, Harrison L, Benaroudj N, Veyrier F, Picardeau M PLoS Pathog. 2024; 20(7):e1012161.
PMID: 39018329 PMC: 11285912. DOI: 10.1371/journal.ppat.1012161.
Evolutionary insights into the emergence of virulent spirochetes.
Giraud-Gatineau A, Nieves C, Harrison L, Benaroudj N, Veyrier F, Picardeau M bioRxiv. 2024; .
PMID: 38617210 PMC: 11014503. DOI: 10.1101/2024.04.02.587687.
Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.
Beard D, Subramanian S, Abendroth J, Dranow D, Edwards T, Myler P Acta Crystallogr F Struct Biol Commun. 2022; 78(Pt 2):45-51.
PMID: 35102892 PMC: 8805214. DOI: 10.1107/S2053230X21013455.