Antimicrobial and Antibiofilm Activity of the Probiotic Strain K12 Against Oral Potential Pathogens

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Jul 2

PMID 34209988

Citations 11

Authors

Andrea Staskova

Miriam Sondorova

Radomira Nemcova

Jana Kacirova

Marian Madar

Affiliations

Soon will be listed here.

Abstract

Oral probiotics are increasingly used in the harmonization of the oral microbiota in the prevention or therapy of various oral diseases. Investigation of the antimicrobial activity of the bacteriocinogenic strain K12 against oral pathogens shows promising results, not only in suppressing growth, but also in eliminating biofilm formation. Based on these findings, we decided to investigate the antimicrobial and antibiofilm activity of the neutralized cell-free supernatant (nCFS) of K12 at various concentrations against selected potential oral pathogens under in vitro conditions on polystyrene microtiter plates. The nCFS of K12 significantly reduced growth ( < 0.01) in Clarke with increasing concentration from 15 to 60 mg/mL and also in 41/6 at a concentration of 60 mg/mL ( < 0.001). Biofilm formation significantly decreased ( < 0.001) in P10 at nCFS concentrations of 60 and 30 mg/mL. Biofilm inhibition ( < 0.001) was also observed in 4/2 at a concentration of 60 mg/mL. In P10 and 4/2, the nCFS had no effect on their growth.

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